PMID: 6789361Jan 1, 1981

Benzodiazepine overdosage: plasma concentrations and clinical outcome

Psychopharmacology
M DivollR I Shader

Abstract

Plasma concentrations and their relation to clinical outcome were evaluated in 21 patients who reached emergency treatment facilities following acute overdosage with benzodiazepine derivatives. Diazepam was implicated in 18 of the 21 cases, with plasma diazepam levels ranging from 585-8,635 ng/ml. In four cases of overdosage with diazepam alone, patients were minimally sedated and were discharged within 24 h, despite diazepam doses as high as 750 mg and plasma levels as high as 4,792 ng/ml. However, concurrent ingestion of diazepam together with other central depressant drugs (such as ethanol, barbiturates, analgesics, or tricyclic antidepressants) produced serious intoxication in 5 of the remaining 14 patients, regardless of the diazepam dosage or plasma concentration. Thus the severity of poisoning following benzodiazepine overdosage is determined largely by co-ingestion of other central depressants rather than the amount of benzodiazepine ingested or its concentration in plasma.

References

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Citations

Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·T R Norman, G D Burrows
Aug 18, 1983·The New England Journal of Medicine·D J GreenblattD R Abernethy
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·I Ben-ShlomoY Katz
May 1, 1985·The American Journal of Emergency Medicine·K R OlsonA Tani
Jan 18, 2014·Journal of Pharmacy Practice·Michael JannGaylord Lopez
Jul 1, 1988·Medical Toxicology and Adverse Drug Experience·F PrischlK Hruby
Sep 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·M Serfaty, G Masterton
Jul 19, 2020·Drug Metabolism and Personalized Therapy·Iyad AliEmile Sahhar
May 29, 2015·Journal of Clinical Psychopharmacology·Anna K GarménJonatan D Lindh

Related Concepts

Benzodiazepines
Tranxilium N
Valium
Dose-Response Relationship, Drug
Drug Augmentation

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