Benzodiazepine receptor interactions may be involved in the neurotoxicity of various penicillin derivatives

Annals of Neurology
A AntoniadisU Wollert

Abstract

The interaction of seven penicillin derivatives with specific [3H]flunitrazepam binding to benzodiazepine receptors was investigated. The affinities of the penicillins for benzodiazepine receptor seemed to depend on the lipophilia of the derivatives. The concentrations of the penicillins which inhibit specific [3H]flunitrazepam binding are consistent with penicillin levels found in the central nervous system of patients developing penicillin induced convulsions. The results suggest that penicillins inhibit GABAergic transmission not only at the GABA receptor, but also at the benzodiazepine receptor, which is thought to be part of a neuronal system facilitating GABAergic transmission. Both mechanisms may account at least in part for the convulsive not neurotoxic properties of penicillins.

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·E Costa, A Guidotti
May 1, 1978·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·H WatanabeM Yamaguchi
Jun 18, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·T R WeihrauchD Höffler
Sep 1, 1971·Archives of Neurology·M E RaichleF McDowell
Apr 18, 1968·The New England Journal of Medicine·K B SeamansJ D Wyant

❮ Previous
Next ❯

Citations

May 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·K J FehskeW E Müller
Nov 2, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K M ChowC C Szeto
Oct 23, 1997·Critical Care Clinics·K L Wallace
Apr 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Matthew Ka Hang TongTze-Hoi Kwan
Jan 1, 1994·Neurochemical Research·A TsudaC Mori
Jan 31, 2008·Journal of Chemotherapy·A E Khalifa
Apr 30, 1998·The Annals of Pharmacotherapy·C L ShafferP Gal
Jan 1, 1992·The Annals of Pharmacotherapy·R W BarronsR M Richey
Jan 1, 1988·Scandinavian Journal of Infectious Diseases. Supplementum·S E Schliamser
Mar 1, 1993·Developmental Medicine and Child Neurology·S Keskin, R J Konkol

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.