PMID: 9555600Apr 29, 1998Paper

Benzodiazepine-receptor ligands in humans: acute performance-impairing, subject-rated and observer-rated effects

Journal of Clinical Psychopharmacology
Craig R RushP J Pazzaglia

Abstract

The study presented here compared the acute performance-impairing, subject-rated, and observer-rated effects of quazepam (15, 30, and 45 mg), triazolam (0.1875, 0.375, and 0.5625 mg), zolpidem (7.5, 15, and 22.5 mg), and placebo in nine healthy, non-drug-abusing humans. Quazepam, a trifluoroethylbenzodiazepine, was chosen for study because, when compared with triazolam, a triazolobenzodiazepine, it is a relatively weak benzodiazepine-receptor ligand, and it may bind selectively to the BZ1 benzodiazepine-receptor subtype. Zolpidem, an imidazopyridine, is the most commonly prescribed hypnotic and was chosen for study because it is biochemically distinct from benzodiazepine hypnotics and also purportedly binds selectively to the BZ1 benzodiazepine-receptor subtype. Triazolam was chosen as the reference compound because it binds nonselectively to BZ1 and BZ2 benzodiazepine-receptor subtypes. Triazolam, zolpidem, quazepam, and placebo were administered orally in a double-blind, crossover design. Triazolam and zolpidem produced orderly dose- and time-related impairment of learning, performance, and recall, and produced sedative-like subject- and observer-rated drug effects. The behavioral pharmacologic profile of zolpidem and triazol...Continue Reading

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Citations

Jul 26, 2006·The American Journal of Drug and Alcohol Abuse·Andrea R VansickelCraig R Rush
Jun 12, 2012·Expert Opinion on Emerging Drugs·Nava Zisapel
Jun 5, 2013·British Journal of Pharmacology·C J Winrow, J J Renger
Mar 21, 2012·Expert Opinion on Pharmacotherapy·Patrick Lemoine, Nava Zisapel
Jun 1, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven V FoxJohn J Renger
Apr 12, 2003·Journal of Psychopharmacology·I A LiappasG N Christodoulou
Jul 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lauren M ReynoldsUwe Rudolph
Mar 20, 2012·Expert Opinion on Pharmacotherapy·David J Greenblatt, Thomas Roth
Oct 31, 2002·Human Psychopharmacology·Craig R. Rush, Robert W. Baker

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