Benzodiazepine receptor quantification in Huntington's disease with [(123)I]omazenil and SPECT

Journal of Neurology, Neurosurgery, and Psychiatry
L H PinborgG M Knudsen

Abstract

Increasing evidence suggests that metabolic changes predate neuronal death in Huntington's disease and emission tomography methods (PET and SPECT) have shown changes in glucose consumption and receptor function in early and possibly even presymptomatic disease. Because the GABA(A)-benzodiazepine receptor complex (BZR) is expressed on virtually all cerebral neurons BZR density images may be used to detect neuronal death. In this study the regional cerebral [(123)I]iomazenil binding to BZR was determined in patients with Huntington's disease and normal controls by a steady state method and SPECT. Seven patients mildly to moderately affected by Huntington's disease and seven age matched controls were studied. Brain CT was performed on all subjects. In each subject two [(123)I]iomazenil-SPECT measurements were acquired-one with and one without infusion of flumazenil. The affinity constant of flumazenil (Kd) was calculated from the paired distribution volumes (DV) and the free plasma flumazenil concentration. The distribution volume of [(123)I]iomazenil in the unblocked condition (DV(0)) reflects the ratio between BZR density and Kd. Flumazenil Kd was similar in the Huntington's disease group and the control group (11.3 v 11.2 mM). ...Continue Reading

References

Jun 27, 1977·Neuroradiology·C F TerrenceM C Alberts
Jan 1, 1979·Neurology·I Shoulson, S Fahn
Nov 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·S G HasselbalchO B Paulson
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A Lassen
Jan 1, 1992·Neurology·W R MartinM R Hayden
Oct 1, 1990·Brain : a Journal of Neurology·T KuwertL E Feinendegen
Nov 13, 1986·The New England Journal of Medicine·J B Martin, J F Gusella
Feb 12, 1987·The New England Journal of Medicine·J C MazziottaJ A Wapenski
Jan 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·D R WeinbergerR F Zec
Sep 1, 1984·Neurology·F O WalkerI Shoulson
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A LassenP N Patsalos
Nov 1, 1993·Journal of Neurology·T KuwertL E Feinendegen
Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·G SedvallL Farde

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Citations

Aug 31, 2013·Current Neurology and Neuroscience Reports·Henning Boecker
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Feb 28, 2003·Seminars in Nuclear Medicine·Hank F KungSeok Rye Choi
Mar 18, 2004·Neuroimaging Clinics of North America·N Scott Mason, Chester A Mathis
Mar 23, 2019·Frontiers in Cellular Neuroscience·Miranda MeleCarlos B Duarte
Sep 22, 2020·Clinical Physiology and Functional Imaging·Anders LassenJens H Henriksen
Mar 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Yoshihide SeharaMikio Sawada

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