PMID: 40258May 1, 1979

Benzodiazepine receptors: cellular and behavioral characteristics

Pharmacology, Biochemistry, and Behavior
A S LippaB Beer

Abstract

Brain specific benzodiazepine receptors appear to mediate the pharmacological properties of benzodiazepines. A neuronal localization for these receptors is suggested by the parallel decrease in the number of benzodiazepine receptors and cerebellar Purkinje cells in "nervous" mutant mice. Electrophysiological results are compatible with an action of benzodiazepines on neuronally localized, physiological receptors. Biochemical, electrophysiological and behavioral experiments highlight the possible importance of frontal cortex in mediating the anxiolytic properties of the benzodiazepines. Triazolenetetrazoles act upon benzodiazepine receptors, increase punished responding and protect against penetylenetetrazole-induced convulsions, but do not produce the side effects associated with benzodiazepines or affect classical neurotransmitter systems. The structural similarities between triazolopyridazines, purines and the indole portion of certain peptides may provide insights into the nature of the endogenous ligand.

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Related Concepts

Metazoa
Anticonvulsants
Benzodiazepines
Drug Interactions
Electrophysiology (Science)
Gammalon
Ligands
Synaptic Transmission
Purkinje Cells
Receptors, Drug

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