PMID: 6105905Oct 13, 1980Paper

Benzodiazepine receptors: the effect of GABA on their characteristics in human brain and their alteration in Huntington's disease

Brain Research
T D ReisineH I Yamamura

Abstract

The characteristics of bezodiazepine (BDZ) receptors were studied in the putamen and substantia nigra (SN) of control and Huntington's disease (HD) human brains. In the putamen, there was a significant decrease in density BDZ receptors in the HD tissue. In addition the application of GABA significantly potentiated DBZ receptor binding in both the HD and control putamen. In the SN, an increase in BDZ receptor density was detected in the HD tissue. GABA enhanced [3H]flunitrazepam binding in both the HD and control SN by increasing the affinity of BDZ receptors for [3H]flunitrazepam. The results suggest that there are alterations in BDZ receptors in HD human brain and that these alterations may be related to the neuronal pathology of this disease. This study also provides evidence for a coupling of GABA receptors to BDZ receptors in human brain.

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Citations

Jun 1, 1989·Metabolic Brain Disease·G Freund, W E Ballinger
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Kato, T Ban
Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Anton van DellenAnthony J Hannan
Oct 27, 2004·Journal of Neuroscience Research·Carlos CepedaMichael S Levine

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