Benzodiazepines modify the agonist responses at a presynaptic GABA receptor

European Journal of Pharmacology
R Mitchell

Abstract

The stimulus-induced release of [3H]glutamic acid from striatal tissue was actively modulated by a presynaptic GABA receptor. The agonist responses of this GABA receptor were modified stereoselectively by benzodiazepines at low concentrations. The results correlate well with effects seen in [3H]GABA binding experiments and as they demonstrate benzodiazepine-induced changes in GABA receptor properties in a tissue prism preparation, these results suggest that the mechanisms described for extensively disrupted preparations may also apply to whole tissue.

References

Apr 1, 1978·Neuropharmacology·P R Mitchell, I L Martin
Sep 12, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·H M GellerB J Hoffer
Jun 16, 1980·Life Sciences·P R Mitchell, N S Doggett

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Citations

Sep 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·S TanganelliL Beani
Dec 19, 1980·European Journal of Pharmacology·R Mitchell, I Martin
Sep 1, 1997·The Journal of Urology·Y H KimK I Glassberg

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