Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity

Journal of Medicinal Chemistry
Stefano RizzoAngela Rampa

Abstract

The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl- N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of Abeta fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect.

References

Mar 15, 1994·Biochemical and Biophysical Research Communications·A KlegerisP L McGeer
Jan 1, 1994·Annual Review of Neuroscience·D J Selkoe
Feb 4, 2003·Nature Reviews. Neuroscience·Sultan DarveshChangiz Geula
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Mar 3, 2004·Journal of Neuroscience Research·Kenjiro OnoMasahito Yamada
Aug 12, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ezio Giacobini
Jan 5, 2005·Trends in Pharmacological Sciences·Moussa B H Youdim, Jerry J Buccafusco
Oct 14, 2005·Journal of Medicinal Chemistry·Richard Morphy, Zoran Rankovic
Nov 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nigel H GreigDebomoy K Lahiri
Oct 20, 2006·Bioorganic & Medicinal Chemistry·Céline RivièreJean-Pierre Monti
Feb 3, 2007·Current Topics in Medicinal Chemistry·L D Estrada, C Soto
Apr 7, 2007·Neuroreport·Ann-Sofi JohanssonAnita Westlind-Danielsson
Aug 22, 2007·Neuroscience Letters·Andrea TarozziPatrizia Hrelia
Oct 17, 2007·Chembiochem : a European Journal of Chemical Biology·Manuela BartoliniVincenza Andrisano
Nov 14, 2007·Bioorganic & Medicinal Chemistry Letters·Lorna PiazziAngela Rampa
Jan 10, 2008·Journal of Medicinal Chemistry·Andrea CavalliCarlo Melchiorre

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Citations

Jul 9, 2013·European Journal of Medicinal Chemistry·Lan-Xiang LiuXiao-Dong Yang
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jerry J Buccafusco
Nov 8, 2011·Journal of Medicinal Chemistry·Maria Laura BolognesiCarlo Melchiorre
Nov 21, 2012·European Journal of Medicinal Chemistry·Stefano RizzoAngela Rampa
Sep 4, 2015·Molecular Diversity·Manjinder SinghOm Silakari
May 23, 2015·Biomolecules & Therapeutics·Jungsook ChoHeesoon Lee
Jul 24, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sehan Lee, Mace G Barron
Aug 6, 2015·European Journal of Medicinal Chemistry·Belma Zengin KurtSalvatore Guccione
Apr 22, 2015·Biomolecules·Afsaneh PorzoorIan Macreadie
Feb 24, 2015·European Journal of Medicinal Chemistry·Ashish Radadiya, Anamik Shah
Dec 22, 2016·Scientific Reports·Urban KošakStanislav Gobec
Sep 17, 2008·Bioorganic & Medicinal Chemistry Letters·Ji Hun ByunKyung Ho Yoo
Jul 8, 2016·Organic & Biomolecular Chemistry·Trapti AggarwalAkhilesh K Verma
Feb 7, 2015·Organic & Biomolecular Chemistry·Mingliang WangXun Sun
Aug 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angela RampaAlessandra Bisi
Dec 1, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiang ZhouLing-Yi Kong
Apr 20, 2010·Chembiochem : a European Journal of Chemical Biology·Manuela Bartolini, Vincenza Andrisano
Jul 28, 2011·Medicinal Research Reviews·Rafael LeónJosé Marco-Contelles
Mar 7, 2019·Current Topics in Medicinal Chemistry·Ankit GaneshpurkarSushil K Singh
Sep 21, 2019·Mini Reviews in Medicinal Chemistry·Yaghoub PourshojaeiAli Asadipour
Sep 22, 2012·Molecular Diversity·Pran Kishore DebRaghuram Rao Akkinepally
Apr 4, 2015·Acta Crystallographica. Section C, Structural Chemistry·Krishnan RavikumarBasi Venkata Subba Reddy

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