Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

Bioorganic & Medicinal Chemistry Letters
Patrizia AlbertiJean-Louis Mergny

Abstract

Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in T(m) value of the G-quadruplex was associated with telomerase inhibition in vitro.

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