PMID: 6975144Jan 1, 1981Paper

Bepridil (CERM-1978) an verapamil depression of contractions of rabbit aortic rings

Blood Vessels
S Mras, N Sperelakis

Abstract

Isolated rings (about 1 mm wide) of rabbit ascending aorta were stimulated to contract by norepinephrine (NE), increased extracellular potassium ion concentration, or electrical stimulation. When tested 20 min after addition, bepridil (CERM-1978) (10(-5)-10(-6) M), a new antianginal agent, and verapamil (10(-5)-10(-6) M) depressed the contractile responses to high K+ (30 mM) and NE (10(-6) M). Bepridil was almost as potent as verapamil in this action. Responses to strong electrical field stimulation were not affected by either agent. The depressed responses to NE in Ca-free EGTA-containing solutions were not further affected by bepridil or verapamil. Contractile responses to NE obtained from depolarized tissues, however, were markedly depressed by bepridil. These results suggest that bepridil, like verapamil, acts to inhibit contractions of vascular smooth muscle by decreasing influx of extracellular Ca++. In depolarized vascular smooth muscle, bepridil may also exert an effect to depress contractions supported by intracellular Ca++ release.

Citations

Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·S IshikawaT Itoh
Apr 24, 1981·European Journal of Pharmacology·S Mras, N Sperelakis
Feb 18, 1983·European Journal of Pharmacology·D C Pang, N Sperelakis
Apr 23, 1985·European Journal of Pharmacology·J J LynchB R Lucchesi
Nov 19, 1986·European Journal of Pharmacology·E WinslowR J Marshall
Jan 28, 1987·European Journal of Pharmacology·J WattsT Harwell

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