Ber-EP4 antigen is a marker for a cell population related to the secondary hair germ

Experimental Dermatology
Maki OzawaHachiro Tagami

Abstract

Ber-EP4 is an antibody to a cell membrane glycoprotein of unknown function. In the skin, Ber-EP4 immunoreactivity has been reported to be localized in structures composed of basaloid epithelial cells, i.e. fetal epithelial germ cells, basal cell carcinoma, and trichoepithelioma as well as eccrine or apocrine ducts. In this study, we further characterized the follicular expression of Ber-EP4 immunoreactivity at different stages of the hair cycle of human terminal hair follicles. In addition, to clarify the location of Ber-EP4(+) cells, we compared the Ber-EP4 immunoreactivity with the expression of keratin 15 and keratin 19. Positive staining by Ber-EP4 was found in the lower part of the epithelial strand of late catagen hair follicles, in the secondary hair germ of telogen hair follicles, and in the matrix of early anagen hair follicles but not in any parts of mature anagen hair follicles. In contrast, the follicular expression of keratin 15 detected by using LHK15 antibody was restricted to two distinct parts of anagen hair follicles, i.e. the outer root sheath above the hair bulb and that of the isthmus including the bulge area, and to the outer root sheath of late catagen and telogen hair follicles. The follicular expression...Continue Reading

References

Jun 1, 1992·The American Journal of Surgical Pathology·M J GaffeyM R Wick
Mar 1, 1990·Journal of Clinical Pathology·U LatzaH Stein
Dec 26, 1991·Annals of the New York Academy of Sciences·E B LaneI M Leigh
May 1, 1991·The Journal of Investigative Dermatology·T T SunR M Lavker
Aug 1, 1991·The American Journal of Surgical Pathology·K SheibaniL M Weiss
Jan 13, 1995·Cell·P H JonesF M Watt
Oct 1, 1993·The American Journal of Dermatopathology·O TellecheaA P Baptista
Mar 1, 1997·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M S JonesM E Maloney
Mar 20, 1999·The Journal of Investigative Dermatology·A WaseemI M Leigh
Apr 17, 1999·Experimental Dermatology·G CotsarelisJ Bickenbach
Aug 10, 1999·Experimental Dermatology·K S Stenn, R Paus
Jan 29, 2000·The Journal of Investigative Dermatology·M AkiyamaH Shimizu
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus
Jul 10, 2001·The Journal of Investigative Dermatology·S Müller-RöverR Paus
Oct 31, 2002·The Journal of Investigative Dermatology·Christopher S Potten, Catherine Booth
Jan 1, 1954·Physiological Reviews·H B CHASE

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Citations

Sep 5, 2009·The American Journal of Dermatopathology·Noriyuki MisagoYutaka Narisawa
Sep 13, 2006·Journal of Cutaneous Pathology·Noriyuki Misago, Yutaka Narisawa
Mar 26, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Talveen S PurbaRalf Paus
Feb 22, 2018·Journal of Skin Cancer·Anthony Paulo SunjayaSukmawati Tansil Tan
Apr 20, 2018·Experimental Dermatology·Andrey A Panteleyev
Aug 30, 2018·Stem Cells International·Agnieszka Owczarczyk-SaczonekJoanna Wojtkiewicz
Mar 8, 2006·Archives of Pathology & Laboratory Medicine·Mai P Hoang, Brian M Levenson

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