Berberine: A nematocidal alkaloid from Argemone mexicana against Strongyloides venezuelensis

Experimental Parasitology
Joel H Elizondo-LuévanoAbelardo Chávez-Montes

Abstract

Strongyloidiasis is a parasitosis that represents a public health problem, in tropical regions. The present study aimed to investigate the anthelmintic effects of several extracts of Argemone mexicana, as well as its main component berberine (Ber) against the third-stage larvae (L3) of Strongyloides venezuelensis in-vitro experiments. Also, the anti-hemolytic activity of the extract, fractions, and Ber were tested in human erythrocytes. A dose-response anthelminthic bioassay demonstrated Ber as the most effective component, followed by methanolic subfraction (Fr3) and finally the crude extract of A. mexicana (Am) showing LC50 response values of 1.6, 19.5, and 92.1 μg/mL, at 96 h respectively. Also, Am, Fr3, and Ber did not produce significant hemolysis against human erythrocytes (p ≤ 0.05). Am and Fr3 showed erythrocyte protection effect capacity at the membrane level (p ≤ 0.05). Furthermore, Ber was found to have an antioxidant activity of 168.18 μg/mL. According to the results, the Fr3 of A. mexicana, and particularly Ber, exhibited potent in-vitro effects against L3 of S. venezuelensis, without hemolytic activity against human erythrocytes and presented good antioxidant capacity. In conclusion, the extracts of A. mexicana an...Continue Reading

Citations

Apr 8, 2021·PloS One·Danielle Annette Orozco-NunnellyTeodora Najdeska
Jul 5, 2021·Veterinary Parasitology·Gisele Dias da SilvaMariana Borges Botura
Sep 2, 2021·The Korean Journal of Parasitology·Binh Thanh NguyenWongi Min

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