Berberine alleviates adipose tissue fibrosis by inducing AMP-activated kinase signaling in high-fat diet-induced obese mice

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Lijun WangYingxiang Song

Abstract

Adipose tissue fibrosis is a novel mechanism for the development of obesity related insulin resistance. Berberine (BBR) has been shown to relieve several metabolic disorders, including obesity and type 2 diabetes. However, the effects of BBR on obesity related adipose fibrosis remain poorly understood. The objective of this study was to assess the effects of BBR on adipose tissue fibrosis in high fat diet (HFD)-induced obese mice. The results showed that BBR reduced animal body weight and significantly improved glucose tolerance in HFD mice. In addition, BBR treatment markedly attenuated collagen deposition and reversed the up-regulation of fibrosis associated genes in the adipose tissue of HFD mice. Moreover, BBR treatment activated AMP-activated kinase signaling and reduced TGF-β1 and Smad3 phosphorylation. Of note, the inhibitory effects of BBR on adipose tissue fibrosis were significantly blocked by AMPK inhibition with compound C, an AMPK inhibitor. Macrophage infiltration and polarization induced by HFD were also reversed after BBR administration. These findings suggest that BBR displays beneficial effects in the treatment of obesity, in part via improvement of adipose tissue fibrosis.

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Citations

Nov 11, 2019·Science China. Life Sciences·Qiuping GuoYulong Yin
May 21, 2020·Nutrients·Maria Pia AdorniNicola Ferri
Mar 7, 2020·Frontiers in Pharmacology·Tarun BelwalJavier Echeverría
Jul 2, 2019·Frontiers in Pharmacology·Jun LiJunping Wei
Dec 16, 2020·Critical Reviews in Food Science and Nutrition·Han-Ning WangMin Du
Jan 8, 2021·Frontiers in Cell and Developmental Biology·Jacopo Di GregorioVincenzo Flati
Nov 14, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinmei XuGang Fan
Mar 31, 2021·Pharmaceutical Research·Youngshim Choi, Liqing Yu
Aug 8, 2021·International Journal of Molecular Sciences·Pamela SenesiIleana Terruzzi
Sep 22, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Mohammed AjebliMohamed Eddouks

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