Berberine and cinnamaldehyde together prevent lung carcinogenesis

Oncotarget
Mingjing MengGangjun Du

Abstract

Starving tumor cells by restricting nutrient sources is a promising strategy for combating cancer. Because both berberine and cinnamaldehyde can activate AMP-activated protein kinase (AMPK, a sensor of cellular energy status), we investigated whether the combination of berberine and cinnamaldehyde could synergistically prevent lung carcinogenesis through tumor cell starvation. Urethane treatment induced lung carcinogenesis in mice, downregulated AMPK and mammalian target of rapamycin (mTOR) while upregulating aquaporin-1 (AQP-1) and nuclear factor kappa B (NF-κB). Together, berberine and cinnamaldehyde reduced mouse susceptibility to urethane-induced lung carcinogenesis, and reversed the urethane-induced AMPK, mTOR, AQP-1, and NF-κB expression patterns. In vitro, berberine and cinnamaldehyde together induced A549 cell apoptosis, prevented cell proliferation, autophagy, and wound healing, upregulated AMPK, and downregulated AQP-1. The effects of the combined treatment were reduced by rapamycin (a mTOR inhibitor) or HgCL2 (an AQP inhibitor), but not Z-VAD-FMK (a caspase inhibitor). The berberine/cinnamaldehyde combination also prevented A549 cell substance permeability and decreased intracellular ATP concentrations. These results...Continue Reading

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Citations

Feb 17, 2019·Journal of Cellular Physiology·Reza MohammadinejadMilad Ashrafizadeh
Feb 23, 2019·Journal of Separation Science·Jiahui WangNing Zhang
Mar 20, 2019·Journal of Translational Medicine·Zibo LiGangjun Du
Jan 8, 2021·Journal of Ovarian Research·Jie LiYu Jiang

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Methods Mentioned

BETA
ELISA
immunoprecipitation assay
flow cytometry
ATP

Software Mentioned

ImageJ
GraphPad Prism

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