Berberine attenuates arthritis in adjuvant-induced arthritic rats associated with regulating polarization of macrophages through AMPK/NF-кB pathway

European Journal of Pharmacology
Jing ZhouFang Wei

Abstract

Berberine (BBR) is a traditional folk medicine with excellent anti-inflammatory properties. This study aimed to investigate the anti-arthritic effects of BBR in adjuvant arthritis (AA) in rats and its regulatory role in the polarization of macrophages. Rats were immunized with Complete Freund's Adjuvant (CFA), and then BBR (40, 80, 160 mg/kg) was administered orally for 14 days. BBR significantly reduced paw swelling and arthritis global assessment as well as alleviated joint destruction and inflammatory cell infiltration. The index of the thymus and thymocyte proliferation were significantly reduced by BBR. Moreover, BBR treatment restrained the phagocytic function of macrophages and restored the balance of M1/M2 by reducing the levels of M1 cytokines (tumour necrosis factor-α, interleukin-1β, and interleukin-6), increasing the levels of M2 cytokines (interleukin-10 and transforming growth factor-β1), increasing the expression of arginase 1(Arg1) (M2 marker) and decreasing the expression of inducible nitric oxide synthase (iNOS) (M1 marker). BBR also downregulated the ratio of Th17/Treg cells. Further research on the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/nuclear factor κB (NF-κB) pathway found that B...Continue Reading

Citations

Aug 17, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wei-Wei CaiFang Wei
Apr 19, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ying WangYingmei Wei
Sep 25, 2020·Journal of Cellular and Molecular Medicine·Peng ShenAmir Abbas Momtazi-Borojeni
Feb 23, 2020·Current Molecular Pharmacology·Vipin K VermaJagriti Bhatia
May 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dan-Na HuangXi-Jun Wang
May 26, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P SivasakthiP Senthamil Selvan

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