Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines

Journal of Chemical Neuroanatomy
Solmaz Nasseri MalekiFaramarz Souri

Abstract

Existing research indicates that anti-inflammatory and antioxidant properties of berberine play major roles in coping with oxidative stress in neurodegenerative diseases, but it is not known if this isoquinoline alkaloid affects inflammatory cytokines such as interleukin 10 in focal cerebral ischemia. Male Wistar rats (10 weeks old) were treated with 40mg/kg concentration of berberine 1h after focal cerebral ischemia and the anti-inflammatory properties of berberine were evaluated by immunohistochemical analysis, water content measure and behavioral tests. Evaluation of infarct volume was performed by TTC staining. Immunohistochemistry and behavioral assessment indicated recovery in treatment group compared to only ischemia group. The infarct volume decreased in treatment group compared to ischemia group. Berberine administration significantly decreased brain edema and contributed to the restoration of motor function. Moreover, berberine potently contributed to neuroprotection in motor area through downregulation of pro-inflammatory cytokines and upregulation of anti-inflammatory cytokines. These findings confirm the validity of berberine as a potent anti-inflammatory agent in treatment of ischemic stroke.

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Nov 23, 2006·Neurology India·Xiangjian ZhangChunyan Li
Aug 8, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chang-Hsien LeeTin-Yun Ho
Oct 8, 2008·Neuroscience Letters·Xi-Qiao ZhouXiu-Lan Sun
Dec 5, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sangmin KimJeong Eon Lee
Feb 12, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hyun Woo JeongJae Bum Kim
Jun 29, 2013·Brain Research·Fatemeh Zare MehrjerdiHamidreza Pazoki-Toroudi
Jul 19, 2013·Journal of Biomedical Nanotechnology·Zhengxia LiuZhirui Guo
Nov 2, 2013·European Journal of Pharmacology·Dhirendra Pratap Singh, Kanwaljit Chopra
Jan 23, 2014·Lancet·Valery L FeiginUNKNOWN Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group
Mar 29, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Zheng LiWei-Jia Kong
Apr 1, 2015·Apoptosis : an International Journal on Programmed Cell Death·Liming YuShiqiang Yu
May 10, 2016·Bioorganic & Medicinal Chemistry Letters·Si-Qi WenCheng-He Zhou
Jun 28, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Natsuyo ShinoharaYasuhiro Kuroda
Jul 28, 2016·Ageing Research Reviews·Hamidreza Pazoki-ToroudiSeyed Mohammad Nabavi

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Citations

Sep 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bharath Kumar VelmuruganChing-Feng Weng
Feb 17, 2018·Neural Regeneration Research·Ghaith Al-BadriAlessandro Castorina
Jul 31, 2020·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Jan 16, 2019·Metabolic Brain Disease·Yusef AbbasiMehdi Mehdizadeh
Aug 12, 2020·Molecular and Cellular Biochemistry·Manman ChenLina Song
Aug 11, 2020·European Journal of Pharmacology·Md Sahab UddinLotfi Aleya
May 20, 2021·Oxidative Medicine and Cellular Longevity·Hui XuMingfu Wang
Apr 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuxue SunHaiyan Huang

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