Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model

Phytotherapy Research : PTR
Li-Hong WangYu-Qian Sun

Abstract

The purpose of this study was to explore the anti-arrhythmic mechanisms of berberine in diabetic rats with myocardial infarction. Sixty rats were divided into four groups: (1) normal control; (2) myocardial infarction group (MI); (3) Type 2 diabetes with myocardial infarction group (T2DM+MI); and (4) Type 2 diabetic with myocardial infarction berberine-treated group (BBR). Berberine (60 mg/kg/day) was administered after coronary artery ligation in the T2DM+MI group for 14 days. Currents were measured using whole-cell patch-clamp techniques. Western blot was performed for quantification of target proteins. The study showed that arrhythmias induced by myocardial infarction were aggravated in diabetic rats. Arrhythmia scores in the MI group were significantly higher than in the control group. Interestingly, the administration of berberine at a dose of 60 mg/kg/d recovered arrhythmia scores (P > 0.05). RMP (Resting membrane potential) which could be recovered by berberine (P < 0.05), was significantly reduced in both the infarction groups. I(K1) current and current density markedly decreased in the MI and T2DM+MI groups (P < 0.05) and could be reversed by berberine (P < 0.05). The relative expression of Kir2.1 in rats in the MI and...Continue Reading

References

Mar 5, 2002·Diabetes Care·J Jaime CaroJudith A O'Brien
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Jun 22, 2005·World Journal of Gastroenterology : WJG·Jing AiBao-Feng Yang
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Citations

Mar 18, 2015·Pharmacology & Therapeutics·Lucy MurfittAshraf Kitmitto
Jun 23, 2015·Cardiovascular Drugs and Therapy·Xinran LiSuhua Yan
Dec 23, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Li-Hong WangHong-Li Shan
Jul 30, 2014·Journal of Cardiovascular Pharmacology·Bo-Wei Wu, Ji-Min Cao
Oct 7, 2014·Journal of Cardiovascular Pharmacology·Cheng-Fang LiuBo-Wei Wu
Nov 30, 2018·Cell Biology International·Songyan MengLihong Wang
Nov 5, 2016·Phytotherapy Research : PTR·Mohsen Imenshahidi, Hossein Hosseinzadeh
Jul 17, 2020·Frontiers in Pharmacology·Jianlin KeWenlong Zhang
Apr 27, 2020·Frontiers of Medicine·Danyang SongDaiming Fan
Apr 6, 2021·Frontiers in Pharmacology·Yun CaiKeji Chen

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