Berberine induces miR-373 expression in hepatocytes to inactivate hepatic steatosis associated AKT-S6 kinase pathway

European Journal of Pharmacology
Chi Han LiYangchao Chen

Abstract

Berberine is a Chinese herbal medicine extracted from rhizoma coptidis that functions to improve insulin resistance, hyperlipidemia, hepatosteatosis and inflammation. Berberine can modify the activity of cell metabolism and signaling pathways by regulating expression of genes. However, the roles and effects of differential microRNA (miRNA) expression induced by berberine treatment are largely unexplored. It is believed that miRNAs expression modified by berberine contributes to its therapeutic effects to diseases such as hepatosteatosis and non-alcoholic fatty liver disease. By identifying novel miRNAs and their putative gene targets associated with abnormal hepatic lipid deposition, the underlying mechanism of these diseases could be established and effective therapies against the diseases could be developed. Here, we used the immortalized hepatocyte cell line MIHA as a model to study the effect of berberine on global miRNA expression profile of hepatocytes. Global miRNA expression levels were measured in berberine-treated MIHA cells by quantitative reverse transcription PCR miRNA panel, and the potential berberine regulated miRNAs were then validated in MIHA and HepG2 cells. MicroRNA-373 (MiR-373) was consistently upregulated...Continue Reading

Citations

Nov 22, 2019·Cellular and Molecular Life Sciences : CMLS·Ivo F MachadoAnabela P Rolo
Aug 12, 2020·Molecular and Cellular Biochemistry·Manman ChenLina Song
Feb 6, 2019·Journal of Immunology Research·Minjuan MaLi Guo
Apr 6, 2021·Veterinary Medicine and Science·JiaGe DaiJianMing Gao
Jun 1, 2021·Phytotherapy Research : PTR·Sapana BansodChandraiah Godugu
Oct 18, 2020·European Journal of Pharmacology·Mengting ZhouYunxia Li

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