Berberine inhibition of electrogenic ion transport in rat colon

British Journal of Pharmacology
C T Taylor, Alan W Baird

Abstract

1. The effects of the alkaloid berberine on basal and stimulated ion transport were investigated in voltage-clamped rat colonic epithelia. 2. Berberine (100-500 microM) reduced basal short circuit current (SCC) when applied basolaterally but not when applied apically. 3. SCC responses to mast cell activation by anti-rat IgE were significantly attenuated in the presence of berberine. 4. Berberine, applied to the basolateral bathing solution, also reduced SCC responses to the following agents which stimulate chloride secretion in rat colon: carbachol, forskolin, sodium nitroprusside, dibutyryl cyclic-AMP, heat-stable E. coli enterotoxin, 8-bromo-cyclic GMP and thapsigargin. Calcium mediated ion transport responses appear to be more sensitive to berberine inhibition than those which are cyclic GMP-mediated, which in turn are more sensitive than cyclic AMP-mediated responses. 5. Berberine added apically was without effect upon forskolin-stimulated ion transport. Cytochalasin D treatment of the lumenal surface of rat colon conferred apical-side sensitivity to berberine. 6. Berberine (at concentrations up to 500 microM) was without effect on generation of cyclic AMP by forskolin or on generation of cyclic GMP by sodium nitroprusside ...Continue Reading

References

Jul 1, 1992·The American Journal of Physiology·A L FinnD L Brautigan
Jul 11, 1992·The American Journal of Physiology·R P Lindeman, H S Chase
Sep 1, 1991·Pflügers Archiv : European journal of physiology·M BöhmeW Rummel
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O ThastrupA P Dawson
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W H Cliff, R A Frizzell
Mar 1, 1986·The American Journal of Physiology·K G MandelK Dharmsathaphorn
Nov 1, 1989·British Journal of Pharmacology·D J BraydenA W Cuthbert
Sep 21, 1989·The New England Journal of Medicine·M FieldE B Chang
Nov 1, 1987·Journal of Pediatric Gastroenterology and Nutrition·S GuandaliniA Rubino
Aug 2, 1988·European Journal of Pharmacology·M DienerW Rummel
May 1, 1986·Reviews of Infectious Diseases·M DonowitzG W Sharp
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·N ArizonoO Takeoka
Jan 1, 1972·British Journal of Pharmacology·N K DuttaN R Rao
Jan 1, 1983·International Archives of Allergy and Applied Immunology·G Berlin, L Enerbäck
Feb 24, 1995·European Journal of Pharmacology·K E O'MalleyA W Baird
Jan 1, 1994·Lancet·G I SandleR B Lomax
Jan 1, 1993·Free Radical Research Communications·H Tamai, T S Gaginella
May 1, 1993·The American Journal of Physiology·A Köckerling, M Fromm
Jun 1, 1993·The Journal of Clinical Investigation·L R ForteM G Currie
Mar 1, 1993·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·K YamamotoA Suzuki

❮ Previous
Next ❯

Citations

Mar 30, 1999·European Journal of Pharmacology·C T TaylorA W Baird
Oct 2, 2012·European Journal of Pharmacology·Mekki MedaniAlan W Baird
Feb 13, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ning LiJieshou Li
Apr 17, 2009·Phytotherapy Research : PTR·W QiuJ X Jin
Jul 5, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cláudia V PereiraPaulo J Oliveira
Jun 17, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S S LinY S Tyan
Dec 10, 1999·Immunopharmacology and Immunotoxicology·N IvanovskaM Hristova
May 18, 2016·World Journal of Gastrointestinal Pathophysiology·Katherine M DiGuilioJames M Mullin
Jan 11, 2007·Bioscience, Biotechnology, and Biochemistry·Nobukazu ShitanKazufumi Yazaki
Sep 2, 2006·Biological & Pharmaceutical Bulletin·Annie ShirwaikarIsaac Sam Raj Punitha
Jul 12, 2008·Phytotherapy Research : PTR·Mohsen Imanshahidi, Hossein Hosseinzadeh
Mar 25, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Pi-Lo Tsai, Tung-Hu Tsai
Apr 27, 2020·Frontiers of Medicine·Danyang SongDaiming Fan
Nov 16, 2002·Journal of Pharmaceutical Sciences·Han-Joo MaengChang-Koo Shim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.