Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice

International Journal of Nanomedicine
Mei XueShu-yu Yang

Abstract

Berberine (BBR) shows very low plasma levels after oral administration due to its poor absorption by the gastrointestinal tract. We have previously demonstrated that BBR showed increased gastrointestinal absorption and enhanced antidiabetic effects in db/db mice after being entrapped into solid lipid nanoparticles (SLNs). However, whether BBR-loaded SLNs (BBR-SLNs) also have beneficial effects on hepatosteatosis is not clear. We investigated the effects of BBR-SLNs on lipid metabolism in the liver using histological staining and reverse transcription polymerase chain reaction analysis. The results showed that oral administration of BBR-SLNs inhibited the increase of body weight and decreased liver weight in parallel with the reduction of serum alanine transaminase and liver triglyceride levels in db/db mice. The maximum drug concentration in the liver was 20-fold higher than that in the blood. BBR-SLNs reduced fat accumulation and lipid droplet sizes significantly in the liver, as indicated by hematoxylin and eosin and Oil Red O staining. The expression of lipogenic genes, including fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD1), and sterol regulatory element-binding protein 1c (SREBP1c) were downregulated, while lip...Continue Reading

Citations

Feb 17, 2019·Journal of Cellular Physiology·Reza MohammadinejadMilad Ashrafizadeh
Jan 31, 2020·Frontiers in Bioengineering and Biotechnology·Alexander VaisermanOleh Lushchak
Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Nov 7, 2019·GeroScience·Oleh LushchakAlexander Vaiserman
Jun 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhe MaZhidong Liu
May 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elaheh MirhadiBizhan Malaekeh-Nikouei
Dec 11, 2019·European Journal of Medicinal Chemistry·Hamed MortazaviAmir Abbas Momtazi-Borojeni
Jun 11, 2020·Current Pharmaceutical Design·Phui Qi NgDinesh Kumar Chellappan
Apr 9, 2021·Advanced Drug Delivery Reviews·Shubham A SalunkheAnupama Mittal
Jul 11, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sepideh MirzaeiGautam Sethi
Sep 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yunfeng HanXianrong Lai

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