Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yao QingLiu Yanhui

Abstract

Berberine has been verified to protect the heart from ischemia/reperfusion injury through animal experiments. However, the cardioprotective properties of berberine have not been established fully. This study was aimed at investigating whether berberine is cardioprotective in vivo and in vitro. In the cardiomyoblast cells, the autophagosomes were observed by immunostaining. The apoptosis was detected by a flow cytometry. Beclin-1, LC3-II/I, adenosine monophosphate-activated protein kinase (AMPK), and mTOR in cardiomyocytes were detected by Western blot. Next, one hundred patients, who were undergoing percutaneous coronary intervention (PCI), were randomly assigned to the berberine group (n = 52) or control group (n = 48). Berberine was administered on them postoperatively. Their plasma was then analyzed for CRP, TNF-α and IL-6. In the cardiomyoblast cells, berberine reduced the autophagy and apoptosis induced by NaH2PO4. At the same time, berberine increased the activation of p-AMPK and inhibited the activation of p-mTOR induced by NaH2PO4. in vivo, berberine significantly reduced the levels of CRP, TNF-α and IL-6 in the patients' plasma. It was concluded that berberine therapy reduced myocardial injury partly by reducing myocar...Continue Reading

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Citations

Feb 17, 2019·Journal of Cellular Physiology·Reza MohammadinejadMilad Ashrafizadeh
Oct 18, 2019·Journal of Cellular and Molecular Medicine·Jiasi WuXianli Meng
May 18, 2020·International Journal of Molecular Sciences·Paola RusminiAngelo Poletti
Jul 31, 2020·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Aug 11, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dai-Qiang LiuDa-Wei Ye
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Xing ChangJiahui Sun
Dec 14, 2021·Frontiers in Cell and Developmental Biology·Liuhua ZhouLiansheng Wang

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