Berberine reduced blood pressure and improved vasodilation in diabetic rats

Journal of Molecular Endocrinology
Yu-Guang MaZhong-Wei Wang

Abstract

Hyperglycemia and hypertension are considered to be the two leading risk factors for vascular disease in diabetic patients. However, few pharmacologic agents could provide a combinational therapy for controlling hyperglycemia and hypertension at the same time in diabetes. The objectives of this study are to investigate whether berberine treatment could directly reduce blood pressure and identify the molecular mechanism underlying the vascular protection of berberine in diabetic rats. Berberine was intragastrically administered with different dosages of 50, 100 and 200 mg/kg/day to diabetic rats for 8 weeks since the injection of streptozotocin. The endothelium-dependent/-independent relaxation in middle cerebral arteries was investigated. The activity of large-conductance Ca2+-activated K+ channel (BKCa) was investigated by recording whole-cell currents, analyzing single-channel activities and assessing the expressions of α- and β1-subunit at protein or mRNA levels. Results of the study suggest that chronic administration of 100 mg/kg/day berberine not only lowered blood glucose but also reduced blood pressure and improved vasodilation in diabetic rats. Furthermore, berberine markedly increased the function and expression of BK...Continue Reading

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Citations

Jul 12, 2019·Current Vascular Pharmacology·Zhiyong WangHao Li
Jul 1, 2020·Archives of Virology·Alicja WarowickaAnna Goździcka-Józefiak
May 29, 2018·Current Cardiology Reports·Vanessa BianconiMatteo Pirro
Sep 8, 2018·Biochemical and Biophysical Research Communications·Younho HanKwang Youl Lee
Sep 14, 2021·Natural Products and Bioprospecting·Oyere Tanyi EbobFidele Ntie-Kang

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