Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice

Neuroscience Letters
Ji-Duo ShenYu-Cheng Li

Abstract

Depression is increasingly become a global public healthy problem. This study was to investigate whether berberine could attenuate the depressive-like behavior induced by repeated corticosterone injection and explore the possible mechanisms. The present results showed that exogenous corticosterone injection caused depressive-like behaviors in mice, such as decreased sucrose intake in sucrose preference test (SPT) and increased immobility time in forced swimming test (FST). These behavioral alterations were accompanying with the decreased BDNF mRNA and protein levels in hippocampus and the elevated serum corticosterone levels. Treatment with berberine prevented these changes above. Our findings confirmed the antidepressant-like effect of berberine and suggested its mechanisms might be partially mediated by up-regulation of BDNF in hippocampus.

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Citations

Jun 2, 2016·Psychoneuroendocrinology·Ping GanQi-Xin Zhou
Nov 20, 2018·Journal of Cellular and Molecular Medicine·Jie FanRanji Cui
Feb 17, 2018·Neural Regeneration Research·Ghaith Al-BadriAlessandro Castorina
Jul 31, 2020·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
May 4, 2017·Scientific Reports·Jie FanRanji Cui
Dec 8, 2017·Journal of Psychopharmacology·Vishnu N ThakareBhoomika M Patel
Jul 31, 2019·Dose-response : a Publication of International Hormesis Society·Guangju ZhouNanwei Tong
Jan 19, 2021·Life Sciences·Fatma H ShakerHala O El-Mesallamy

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