BerEP4-negative basal cell carcinoma on the palm: case report and review of the literature

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Anna MleczkoMartin Leverkus

Abstract

Only 10 cases of patients with isolated basal cell carcinoma (BCC) of the palms and soles have been published. We describe a patient with an isolated basal cell carcinoma of the palm. Our patient denied injury and exposure to noxious agents; he did not have basal cell nevus syndrome. The tumor was negative for EpCAM as determined by BerEP4 immunohistochemistry, although EpCAM expression usually is seen in BCC in more conventional locations. Because the tumor cells were connected to secretory eccrine glands, we speculate that BCC of the palm originates from common progenitor cells of eccrine glands or epidermal stem cells. We review the literature on these rare BCC in atypical anatomical regions, and discuss the cellular origin of BCC in such locations.

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Citations

Oct 22, 2013·Actas dermo-sifiliográficas·M J Alonso-CorralR Ruiz-Villaverde
Mar 8, 2012·The Journal of Dermatology·Takahiro KiyoharaMasanobu Kumakiri
Jun 21, 2018·Anais Brasileiros De Dermatologia·Maura Simonetti Junqueira BourroulUbirajara Honorato da Silva
Jan 4, 2019·International Journal of Dermatology·John J DávilaAsiclo Boadas
Jan 1, 2018·Anais Brasileiros De Dermatologia·Maura Simonetti Junqueira BourroulAnderson da Costa Lino Costa

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