Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jeong-Hyeon KoKwang Seok Ahn

Abstract

Bergamottin (BGM) is a naturally occurring furanocoumarin and is known to inhibit the growth of tumor cells. However, there is no available evidence that BGM has an inhibitory effect on cancer metastasis, specifically on the epithelial-to-mesenchymal transition (EMT) process in the malignant cells. Here we aimed to evaluate the antimetastatic potential of BGM in human lung adenocarcinoma cells. Our results demonstrate that BGM can block EMT, and observed inhibition was accompanied by downregulation of fibronectin, vimentin, N-cadherin, twist and snail expression, and upregulation of occludin and E-cadherin. Interestingly, transforming growth factor-β (TGF-β)-induced upregulation of fibronectin, vimentin, N-cadherin, twist and snail, and downregulation of occludin and E-cadherin, were abrogated by BGM treatment. Moreover, the treatment of BGM repressed TGF-β-induced cell invasive potential. BGM treatment also inhibited multiple oncogenic cascades such as PI3K/Akt/mTOR. Overall, the results demonstrate the potential antimetastatic activity of BGM against lung cancer cells.

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Citations

Feb 23, 2019·Cancers·Bethsebie Lalduhsaki SailoAjaikumar Bahulayan Kunnumakkara
May 9, 2019·Biomolecules·Dharambir KashyapSardul Singh Sandhu
May 6, 2019·Cancers·Samantha Kah Ling OngAnupam Bishayee
Jun 30, 2019·Biomolecules·Nand Kishor RoyAjaikumar B Kunnumakkara
Mar 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shanaya RamchandaniKwang Seok Ahn
Jun 7, 2020·International Journal of Molecular Sciences·Milad AshrafizadehGautam Sethi
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sosmitha GirisaAjaikumar B Kunnumakkara
Aug 13, 2020·International Journal of Molecular Sciences·Salman AhmedRaffaele Capasso
Dec 19, 2018·International Journal of Molecular Sciences·Jeong-Hyeon KoKwang Seok Ahn
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min Hee YangKwang Seok Ahn
Nov 11, 2020·International Journal of Molecular Sciences·Min Hee YangKwang Seok Ahn
Apr 24, 2020·Seminars in Cancer Biology·Chakrabhavi Dhananjaya MohanKanchugarakoppal S Rangappa
Sep 12, 2020·BMJ Open Respiratory Research·Zhenlin LiOnnik Agbulut
Apr 4, 2021·International Journal of Molecular Sciences·Kumar RishabhAjaikumar B Kunnumakkara
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Sep 25, 2021·The Journal of Pharmacy and Pharmacology·Min Hee YangKwang Seok Ahn

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