Bergapten prevents lipopolysaccharide-induced inflammation in RAW264.7 cells through suppressing JAK/STAT activation and ROS production and increases the survival rate of mice after LPS challenge

International Immunopharmacology
Yi ZhouZhimin Yin

Abstract

Bergapten (BG) is a cumarine-derivate compound in many medicinal plants. Here, in vitro and in vivo experimental results indicated that BG possesses anti-inflammatory properties, Based on this, we further investigated the precise molecular mechanisms of BG in LPS-stimulated inflammation response. Studies revealed that BG inhibited LPS-stimulated productions of TNF-α, IL-1β, IL-6, PGE2 and NO as well as the expression of iNOS and COX-2, and at the same time, it increased LPS-induced release of IL-10 in a dose-dependent manner in RAW264.7 cells. Mechanistically, BG suppressed the activations of JAK/STAT, but not that of MAPKs and NF-κB. In addition, BG, as an antioxidant, prevented the accumulation of ROS, which further exerted its anti-inflammatory function. In vivo researches revealed that BG decreased LPS-induced mortality in mice. In conclusions, BG may be a potential candidate for inflammation therapy via inhibiting JAK/STAT activation and ROS production in RAW264.7 cells.

Citations

May 12, 2018·Molecular Nutrition & Food Research·Jing-Jing Zhu, Jian-Guo Jiang
Sep 10, 2020·Frontiers in Neuroscience·Joanna KowalczykBarbara Budzyńska
Jul 28, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Zhenyan SongShaowu Cheng
Aug 12, 2020·Lymphatic Research and Biology·Sandro MicheliniFrancesco G Albergati
Sep 5, 2020·Heliyon·Emmanuel A AdakuduguDavid D Obiri
Feb 14, 2021·International Journal of Molecular Sciences·Łukasz KurachBarbara Budzyńska
Mar 27, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lijie DongXiaorong Li
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Aug 18, 2021·The Journal of Pharmacology and Experimental Therapeutics·Liang WangJingyu Wang

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