Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus.

Journal of Agricultural and Food Chemistry
Li-Shu WangG D Stoner

Abstract

Biodirected fractionation is used to identify the active inhibitory constituents in berries for esophageal cancer in rats. The present study was undertaken to determine if ellagitannins contribute to the chemopreventive activity of an alcohol/water-insoluble (residue) fraction of berries. Rats consumed diets containing residue fractions of three berry types, that is, black raspberries (BRBs), strawberries (STRWs), and blueberries (BBs), that differ in their content of ellagitannins in the order BRB > STRW > BB. Animals were fed residue diets beginning 2 weeks before treatment with the esophageal carcinogen N-nitrosomethylbenzylamine (NMBA) and throughout the 30-week bioassay. Residue fractions from all three berry types were about equally effective in reducing NMBA tumorigenesis in the rat esophagus irrespective of their ellagitannin content (0.01-0.62 g/kg of diet). These results suggest that the ellagitannins may not be responsible for the chemopreventive effects of the alcohol/water-insoluble fraction of berries.

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Citations

Dec 19, 2013·Journal of Agricultural and Food Chemistry·Junnan GuYael Vodovotz
Nov 3, 2011·Nutrition and Cancer·Harini S AiyerRobert C G Martin
Dec 25, 2015·Nutrition and Cancer·Marta Kula, Mirosława Krauze-Baranowska
Apr 13, 2015·Food Chemistry·Fernanda M F RoleiraFernanda Borges
Dec 19, 2013·Critical Reviews in Food Science and Nutrition·Arpita BasuTimothy J Lyons
May 18, 2016·Toxins·Tariq IsmailPiero Sestili
Jun 14, 2017·Critical Reviews in Food Science and Nutrition·Bincy BabyRanjit Vijayan
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oksana Golovinskaia, Chin-Kun Wang

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