Best Methods of Communicating Clinical Trial Data to Improve Understanding of Treatments for Patients with Multiple Sclerosis

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Gurpreet K ReenDawn W Langdon

Abstract

Patients' understanding of treatment risks and benefits is a prerequisite for shared decision making. Yet, patients with multiple sclerosis (MS) do not accurately understand treatment information provided in regular clinical consultations. To identify the best methods of communicating clinical trial data to improve the understanding of treatments among patients with MS and to also examine the relationship between patients' understanding with decisional conflict, individual traits, and MS symptoms. A repeated-measures study was used. A sample of relapsing-remitting patients with MS was recruited from National Health Service sites in the United Kingdom. Patients were presented with hypothetical treatment risks and benefits from faux clinical trials. Treatments were communicated using absolute terms, relative terms, and numbers needed to treat/harm. The presence of baseline information with each method was also manipulated. Patients' understanding and conflict in treatment decisions were assessed. Individual traits and MS symptoms were also recorded. Understanding was better when treatments were communicated in absolute terms (mean 3.99 ± 0.93) compared with relative terms (mean 2.93 ± 0.91; P < 0.001) and numbers needed to treat/...Continue Reading

Citations

Nov 11, 2018·Neurology and Therapy·David YeandleDawn Langdon
Jan 12, 2021·International Journal of MS Care·Anne Christin RahnUNKNOWN Rehabilitation in Multiple Sclerosis (RIMS) Special Interest Group on Patient Autonomy
Dec 15, 2020·Neuro-oncology Practice·Andrea PaceLinda Dirven
Jan 30, 2021·Multiple Sclerosis and Related Disorders·Gurpreet K ReenDawn W Langdon

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