Best practice guidelines for the management of adverse events associated with amphotericin B lipid complex

Expert Opinion on Drug Safety
Charles CraddockJohn-Liu Yin

Abstract

Amphotericin B lipid complex is a widely used lipid-based formulation of amphotericin B, which has a broad spectrum of activity against a variety of fungal pathogens. It has also been shown to be significantly less nephrotoxic than conventional amphotericin B. However, infusional drug reactions, similar to those seen when using conventional amphotericin B, have been reported in a significant number of patients, so it is important that these are prevented or managed effectively, particularly in light of the changing epidemiology of systemic fungal infections. This article reviews effective strategies that can be used to reduce the risk of drug delivery reactions associated with amphotericin B lipid complex. Preserving renal function and managing spikes in serum creatinine levels are also discussed. The aim of this paper is to provide healthcare professionals with clear guidance on the management of adverse events associated with amphotericin B lipid complex. Recommendations are based upon the published evidence and clinical experience from a number of different centres. Amphotericin B lipid complex represents a valuable therapeutic option in the treatment of fungal infections but improved strategies for the management of infusio...Continue Reading

References

Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S D GoodwinT H Grasela
Feb 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P K SharkeyD S Gordon
Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T J WalshE J Anaissie
Aug 26, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M H WhiteC B Miller
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Wong-BeringerB J Guglielmo
Feb 16, 2000·Bone Marrow Transplantation·M FurebringJ Sjölin
Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R WingardUNKNOWN L Amph/ABLC Collaborative Study Group
Oct 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Singh
Jan 22, 2002·The Journal of Antimicrobial Chemotherapy·Gilbert Deray
Feb 28, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Ph. ClevenberghJ.P. Thys
Jul 30, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Raleigh BowdenJohn R Wingard
Aug 19, 2003·Pharmacotherapy·John D ClearyStanley W Chapman
Feb 24, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Bruno ContiTamas Bartfai
Sep 10, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J-M AguadoUNKNOWN Grupo de Farmacovigilancia de Abelcet
Feb 11, 2005·The Pediatric Infectious Disease Journal·Joseph M WileyThomas J Walsh
Apr 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara D Alexander, John R Wingard
Feb 9, 2007·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·David W Warnock

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Citations

Nov 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dimitrios FarmakiotisDimitrios P Kontoyiannis
Feb 22, 2016·Infectious Disease Clinics of North America·Dimitrios Farmakiotis, Dimitrios P Kontoyiannis
Mar 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AaproA Ravaud
Feb 2, 2021·Infectious Diseases and Therapy·Francelise B CavassinFlávio Queiroz-Telles

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