Best practices in bioassay development to support registration of biopharmaceuticals

BioTechniques
John R WhitePin Yee Wong

Abstract

Biological activity is a critical quality attribute for biopharmaceuticals, which is accurately measured using an appropriate relative potency bioassay. Developing a bioassay is a complex, rigorous undertaking that needs to address several challenges including modelling all of the mechanisms of action associated with the biotherapeutic. Bioassay development is also an exciting and fast evolving field, not only from a scientific, medical and technological point of view, but also in terms of statistical approaches and regulatory expectations. This has led to an industry-wide discussion on the most appropriate ways to develop, validate and control the bioassays throughout the drug lifecycle.

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Citations

Jul 24, 2021·International Journal of Pharmaceutics·Yu Zoe ZhangTristan Marshall

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Methods Mentioned

BETA
enzyme-linked
surface-plasmon
resonance

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