Best practices in diagnostic immunohistochemistry: workup of cutaneous lymphoid lesions in the diagnosis of primary cutaneous lymphoma

Archives of Pathology & Laboratory Medicine
Rajan DewarLawrence M Weiss

Abstract

Primary cutaneous lymphoma is a common extranodal non-Hodgkin lymphoma. These lesions share common features with their nodal counterparts, but also have differences in morphology, unique clinical presentations, and immunohistochemical features. To review the 2008 World Health Organization (WHO) and 2005 consensus WHO-EORTC (European Organisation for Research and Treatment of Cancer) classifications, and address the immunohistochemical findings in the most common primary cutaneous T- and B-cell lymphomas. Since clonality testing is commonly used as an ancillary test in the evaluation of cutaneous lymphoma, a brief section in the use and pitfalls of clonality testing is included. The WHO and EORTC classification publications and the relevant recent literature were used to compile appropriate and practical guidelines in this review. The practice of dermatopathology and hematopathology varies widely. Thus, while this review provides an overview and guideline for the workup of lymphoid lesions of the skin, the practitioner should understand the importance of clinical correlation as well as appropriate utility of available resources (such as clonality testing) in arriving at a diagnosis in cutaneous lymphoid lesions.

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Citations

Dec 1, 2010·Genome Biology·Shuzhao LiMarius Brouwer
May 18, 2016·The Journal of Investigative Dermatology·Sarah MenguyBéatrice Vergier
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Jun 21, 2019·Virchows Archiv : an International Journal of Pathology·Etan MarksYanhua Wang
Jun 13, 2020·Frontiers in Oncology·Paola VitielloGiuseppe Argenziano
Oct 27, 2021·JAAPA : Official Journal of the American Academy of Physician Assistants·Haley D Kostecki

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