Best Prophylactic Strategy in Groups at Risk of Intraoperative Floppy Iris Syndrome Development: Comparison Between Atropine Instillation and Adrenaline Intracameral Injection

The Open Ophthalmology Journal
Raffaele NuzziFederico Tridico

Abstract

Intraoperative Floppy Iris Syndrome (IFIS) is an important cause of surgical complications and iris defects in patients undergoing phacoemulsification that were treated with selective subtype α1A receptor antagonists for a long period of time. To date, no definitive preventive strategy has emerged, yet. The need of prophylaxis is dictated by the high prevalence of males affected by benign prostatic hyperplasia undergoing cataract surgery. To identify the best prophylactic strategy in groups at risk of IFIS development by comparing two mydriatic treatments in course of phacoemulsification surgery. 81 eyes of 81 patients in treatment with Tamsulosin were enrolled in the study. 43 eyes were treated with atropine sulfate 1% while 38 eyes received an injection of mydriatic solution containing epinephrine in the anterior chamber. All phacoemulsifications were videotaped in order to assess the occurrence of IFIS and the severity of the syndrome. The treatment group showed a statistically significant reduction (p = 0.0115) of floppy iris syndrome incidence, from 86.05% (37/43) of the atropine group to 60.53% (23/38). The analysis showed a reduction of IFIS mild form only, whereas the incidence of severe forms remained unchanged. We bel...Continue Reading

References

Nov 7, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shiow-Wen LiouI-Jong Wang
May 19, 2005·Journal of Cataract and Refractive Surgery·David F Chang, John R Campbell
Feb 14, 2006·Journal of Cataract and Refractive Surgery·Edward Pringle, Richard Packard
Jul 22, 2006·Journal of Cataract and Refractive Surgery·Joel K Shugar
Nov 26, 2008·Journal of Cataract and Refractive Surgery·David F ChangUNKNOWN ASCRS Cataract Clinical Committee
Mar 6, 2010·Journal of Cataract and Refractive Surgery·Richard Schulze

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Citations

Feb 29, 2020·Clinical Ophthalmology·Chrysanthos D ChristouArgyrios Tzamalis
Sep 15, 2020·Journal of Cataract and Refractive Surgery·Gary J L FosterAbhay R Vasavada
Jun 30, 2021·International Ophthalmology·Amit Kumar, Amit Raj
Oct 16, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tal SharonMargarita Safir
Oct 30, 2021·Current Opinion in Ophthalmology·Sally S E ParkNick Mamalis

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