BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironment

Journal of Leukocyte Biology
Guillaume AndrieuGerald V Denis

Abstract

Obesity and its associated pathology Type 2 diabetes are two chronic metabolic and inflammatory diseases that promote breast cancer progression, metastasis, and poor outcomes. Emerging critical opinion considers unresolved inflammation and abnormal metabolism separately from obesity; settings where they do not co-occur can inform disease mechanism. In breast cancer, the tumor microenvironment is often infiltrated with T effector and T regulatory cells programmed by metabolic signaling. The pathways by which tumor cells evade immune surveillance, immune therapies, and take advantage of antitumor immunity are poorly understood, but likely depend on metabolic inflammation in the microenvironment. Immune functions are abnormal in metabolic disease, and lessons learned from preclinical studies in lean and metabolically normal environments may not translate to patients with obesity and metabolic disease. This problem is made more urgent by the rising incidence of breast cancer among women who are not obese but who have metabolic disease and associated inflammation, a phenotype common in Asia. The somatic BET proteins, comprising BRD2, BRD3, and BRD4, are new critical regulators of metabolism, coactivate transcription of genes that en...Continue Reading

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Citations

Mar 22, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·T KuloğluS Aydin
Jul 25, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jianle WangXiaolei Zhang
Nov 22, 2019·Clinical Science·Ratana LimMartha Lappas
Nov 26, 2020·Life Science Alliance·Hongtao ShenLian-Wang Guo
Jul 2, 2021·Analytical Cellular Pathology (Amsterdam)·Yu-Gui ZhangXing-Ke Yan
Jul 24, 2021·Journal of Applied Statistics·Joseph WuLouis Gerstenfeld
Aug 14, 2021·Frontiers in Molecular Biosciences·Pablo García-Gutiérrez, Mario García-Domínguez
Aug 28, 2021·Biomolecules·Nieves Lara-Ureña, Mario García-Domínguez
Sep 15, 2021·Cancer Investigation·Haiyu NiuChangping Wu

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