PMID: 8590804Dec 1, 1995Paper

BET3 encodes a novel hydrophilic protein that acts in conjunction with yeast SNAREs

Molecular Biology of the Cell
G RossiSusan Ferro-Novick

Abstract

Here we report the identification of BET3, a new member of a group of interacting genes whose products have been implicated in the targeting and fusion of endoplasmic reticulum (ER) to Golgi transport vesicles with their acceptor compartment. A temperature-sensitive mutant in bet3-1 was isolated in a synthetic lethal screen designed to identify new genes whose products may interact with BET1, a type II integral membrane protein that is required for ER to Golgi transport. At 37 degrees C, bet3-1 fails to transport invertase, alpha-factor, and carboxypeptidase Y from the ER to the Golgi complex. As a consequence, this mutant accumulates dilated ER and small vesicles. The SNARE complex, a docking/fusion complex, fails to form in this mutant. Furthermore, BET3 encodes an essential 22-kDa hydrophilic protein that is conserved in evolution, which is not a component of this complex. These findings support the hypothesis that Bet3p may act before the assembly of the SNARE complex.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 2, 1992·Gene·T W ChristiansonP Hieter
May 9, 1991·Nature·G RossiS Ferro-Novick
Jul 1, 1990·The Journal of Cell Biology·M E GroeschS Ferro-Novick
Aug 1, 1981·Cell·P NovickR Schekman
Jan 1, 1982·The Journal of Cell Biology·D LouvardG Warren
Dec 15, 1994·Nature·J P LianS Ferro-Novick
Jul 21, 1994·Nature·S Ferro-Novick, R Jahn
Jun 2, 1994·Nature·B DujonP Bossier
Jan 1, 1993·Annual Review of Cell Biology·S Ferro-Novick, P Novick
Mar 25, 1993·Nature·G Warren
Mar 25, 1993·Nature·T SöllnerJ E Rothman

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Citations

May 10, 2000·Trends in Cell Biology·W GuoP Novick
Dec 6, 2001·Traffic·D W KimS Ferro-Novick
Dec 21, 2004·Nature Structural & Molecular Biology·Yeon-Gil KimByung-Ha Oh
Dec 5, 2000·Molecular Biology of the Cell·S JonesN Segev
Mar 4, 2000·The EMBO Journal·J BarrowmanS Ferro-Novick
Apr 13, 2011·Cold Spring Harbor Perspectives in Biology·Andrés Lorente-Rodríguez, Charles Barlowe
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Daniel Ungar, Frederick M Hughson
Jan 21, 2011·Physiological Reviews·Alex H Hutagalung, Peter J Novick
Oct 20, 2005·Journal of Bioscience and Bioengineering·K Yoda, Y Noda
Feb 12, 2013·Genetics·Charles K Barlowe, Elizabeth A Miller
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel KümmelMichael Veit
Nov 6, 2009·FEBS Letters·Elizabeth Sztul, Vladimir Lupashin
Nov 30, 2005·The Journal of Cell Biology·Huaqing CaiSusan Ferro-Novick
Oct 19, 2000·The Journal of Cell Biology·W WangS Ferro-Novick
Aug 2, 2006·The Journal of Cell Biology·Sidney YuSusan Ferro-Novick
Jun 12, 1998·The Journal of Cell Biology·S M VanRheenenM G Waters
Oct 6, 2000·The Journal of Cell Biology·I M EthellY Yamaguchi
Sep 20, 2008·Traffic·Michael SacherNava Segev
Jun 12, 2014·Traffic·Stephanie Brunet, Michael Sacher
Jan 12, 2010·Traffic·Anthony SclafaniSusan Ferro-Novick
Jul 23, 2014·Traffic·Stephanie Brunet, Michael Sacher
May 7, 2010·The Journal of General Virology·Muhammad Atif ZahoorHiroomi Akashi
Jan 13, 2015·Cell Biology International·Shenshen ZouYongheng Liang
Jun 23, 1998·Current Biology : CB·J M Edwardson
Jul 21, 2010·Seminars in Cell & Developmental Biology·Cortney G Angers, Alexey J Merz
Mar 10, 2001·Molecular Cell·M SacherS Ferro-Novick
Jun 6, 2000·Current Biology : CB·M Lowe
Jun 28, 2005·Biochimica Et Biophysica Acta·Vladimir Lupashin, Elizabeth Sztul
Aug 26, 1998·Biochimica Et Biophysica Acta·B J Nichols, H R Pelham
Dec 24, 2017·The Journal of Cell Biology·Falko RiedelSean Munro
Sep 5, 2002·Yeast·Chun-jiang ZhangRichard A Kahn
Mar 6, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Melanie C TheinAntony P Page
Dec 13, 2005·American Journal of Physiology. Cell Physiology·Elizabeth Sztul, Vladimir Lupashin
Mar 6, 2002·The Journal of Biological Chemistry·Thierry FerreiraCarolyn W Slayman
Oct 4, 2002·The Journal of Biological Chemistry·Se Bok JangByung-Ha Oh
Feb 24, 2001·Traffic·M G Waters, F M Hughson

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