beta- and gamma-catenin expression in oral dysplasia

Oral Oncology
L Lo MuzioSergio Gandolfo

Abstract

Cell-cell and cell-matrix interactions regulate important cellular functions; they involve a number of specialised molecules and the corresponding receptors, among which a key role is played by cadherins and the associated catenins. Deregulation of these molecules has been associated with tumour progression in many human malignancies. While catenins expression has been extensively studied in many human cancers, including oral carcinoma (OSCC), less is known about their expression in oral epithelial dysplasia. The objective of this study was to evaluate the expression of these proteins in a large group of displastic lesions of the oral mucosa and their relation with subsequent malignant transformation. Expression of beta- and gamma-catenin was investigated by immunohistochemistry using specific monoclonal antibodies in 49 cases of oral epithelial dysplasia and 10 samples of normal oral mucosa. The presence and absence of beta- and gamma-catenin staining was expressed differently in relation to dysplasia grade; while the degree of dysplasia became more severe, we observed a statistically significant loss and/or reduction of catenins expression, the loss of the exclusive membranous expression and a cytoplasmic delocalisation. Prog...Continue Reading

References

Aug 26, 1998·The American Journal of Pathology·J A Efstathiou, M Pignatelli
Mar 14, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L SchandlP Malfertheiner
Sep 11, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Agnes BánkfalviJozsef Piffkó
Jun 18, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Ji LiuYong-Kie Wong
Jan 12, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shan GaoJens Ahm Sørensen
May 27, 2005·International Journal of Oral and Maxillofacial Surgery·T FilliesR Werkmeister
Sep 16, 2005·Journal of Cancer Research and Clinical Oncology·Soichi IwaiYoshiaki Yura
Jan 10, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kevin A KurtzRobert A Robinson

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Citations

Feb 23, 2013·Clinical Oral Investigations·Marianthi KyrodimouIoannis S Vizirianakis
Nov 12, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gayani PitiyageSaman Warnakulasuriya
Jun 19, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Brunno Santos de Freitas SilvaDécio dos Santos Pinto Júnior
Sep 19, 2014·Journal of Oral Science·Sohichi AizawaHiromasa Hasegawa
Nov 6, 2015·Journal of Applied Oral Science : Revista FOB·Brunno Santos de Freitas SilvaFernanda Paula Yamamoto-Silva
Jul 8, 2020·International Journal of Molecular Sciences·Montserrat ReyesVicente A Torres

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