Beta 1- and beta 2-adrenoceptor-mediated secretion of amylase from incubated rat parotid gland

Acta Physiologica Scandinavica
B CarlsööR Henriksson

Abstract

The present in vitro investigation was undertaken in an attempt to obtain further information on beta-adrenoceptor specificity and action in the rat parotid gland, with regard to amylase secretion. The beta 1-selective agonist prenalterol was roughly 800 times more potent than the beta 2-agonist terbutaline, and about 5 times more effective than noradrenaline in evoking amylase release . Propranolol was the most effective inhibitor of amylase release in all experiments. The beta 1-selective antagonist metoprolol and H104 /08 were also effective blockers of maximal noradrenaline- and prenalterol-induced release. The inhibition curves displayed biphasic shapes when amylase secretion was induced by noradrenaline, but not when prenalterol was the secretagogue. The beta 2-antagonist H35 /25 was without effect on maximal noradrenaline- and prenalterol-stimulated secretion. The amylase release evoked by submaximal concentration of terbutaline was inhibited by the two antagonists H35/25 and IPS 339. In another series of experiments propranolol and metoprolol clearly shifted the noradrenaline concentration-response curve to the right, whereas H35/25 was without effect. The results further demonstrate the major importance of the beta 1-a...Continue Reading

References

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Citations

Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K Abe
Oct 1, 1987·Acta Physiologica Scandinavica·G JönssonS Sundström
Feb 19, 2010·American Journal of Physiology. Cell Physiology·Ching-Yi WuEileen L Watson
Sep 26, 2000·Experimental and Molecular Pathology·M J GonzálezR O López Solís
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G S Bedi
Feb 5, 2011·European Journal of Pharmacology·Kazunori OuchiMitsuru Kawaguchi

Related Concepts

H 35-25, hydrochloride, (+-)-isomer
IPS 339, monohydrochloride, (+-)-isomer
Pamatolol sulfate (2: 1)
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Amylases
Sal-Phedrine
Betalok
Norepinephrine, (+, -)-Isomer
Parotid Gland

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