Beta 1-adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

British Journal of Pharmacology
P J Henry, R G Goldie


1. The relaxant effects to the beta-adrenoceptor agonists isoprenaline, adrenaline, noradrenaline, RO363, procaterol and fenoterol were investigated in carbachol-contracted mouse isolated tracheal preparations. 2. The order of potencies for those beta-adrenoceptor agonists that induced full relaxation of carbachol-contracted mouse tracheal preparations was isoprenaline greater than RO363 greater than noradrenaline = adrenaline greater than fenoterol. The EC50 value of isoprenaline for relaxation was 46 nM. The beta 1-adrenoceptor-selective agonist, RO363 was ten times more potent than the beta 2-adrenoceptor-selective agonist, fenoterol. The highly beta 2-adrenoceptor-selective agonist procaterol was a partial relaxant and induced only 28 +/- 4% relaxation. 3. Relaxations induced by noradrenaline and isoprenaline were not significantly affected by the neuronal uptake inhibitor, cocaine (10 microM) or by the extraneuronal uptake inhibitor, deoxycorticosterone acetate (25 microM) respectively. The alpha-adrenoceptor agonist methoxamine induced no observable elevation of mouse tracheal smooth muscle tone. 4. Schild plots for the beta-adrenoceptor antagonists, atenolol and betaxolol (beta 1-adrenoceptor-selective) and ICI 118,551 (...Continue Reading


May 15, 1978·European Journal of Pharmacology·R D Krell
Jan 21, 1974·JAMA : the Journal of the American Medical Association·T E MinorC E Reed
Apr 1, 1984·British Journal of Pharmacology·R G GoldieJ L Wale
Apr 1, 1984·British Journal of Pharmacology·S R O'Donnell, J C Wanstall
May 1, 1983·British Journal of Pharmacology·R G GoldieJ L Wale
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD


Jan 1, 1993·Life Sciences·K J MorrisonP M Vanhoutte
Jan 1, 1990·Pharmacology & Therapeutics·R G GoldieK M Lulich
Feb 1, 1993·Pharmacology & Therapeutics·Y D Pendry
Nov 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Neil S HoldenRobert Newton
Nov 6, 2013·American Journal of Respiratory Cell and Molecular Biology·Jane E BourkeMichael J Sanderson
May 6, 2008·European Journal of Pharmacology·Khaled Al ZubairJames R Docherty
Oct 21, 2014·Clinical Science·Paul F MercerRichard G Knowles
Mar 16, 2018·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Daisuke ChinoYoshio Tanaka
Jun 25, 2004·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshio TanakaKatsuo Koike
Feb 8, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·G DorionY Cormier
Sep 11, 2014·British Journal of Pharmacology·Mark A BirrellMaria G Belvisi
Sep 8, 2018·PloS One·Yoshitaka KawaYoshihiro Nishimura
Jun 6, 2020·Clinical Science·Mikael AdnerSven-Erik Dahlén
Apr 1, 2015·British Journal of Pharmacology·Eva WexPhilippe Devillier
Jan 1, 1994·Epilepsia·H Mengel
Sep 20, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chantal DonovanJane E Bourke
Jul 10, 2020·Advanced Drug Delivery Reviews·T SécherN Heuzé-Vourc'h

Related Concepts

ICI 118551, hydrochloride
Cocaine Hydrochloride
Mice, Inbred CBA
Muscle Relaxation Phase
Smooth Muscle
Norepinephrine, (+, -)-Isomer

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.