PMID: 6115005Jun 1, 1981

beta 1-Adrenoceptors mediating relaxation of the guinea-pig trachea: experiments with prenalterol, a beta 1-selective adrenoceptor agonist

The Journal of Pharmacy and Pharmacology
U Johansson, B Waldeck

Abstract

In the presence of 17 beta-oestradiol, prenalterol, a beta-selective adrenoceptor agonist, caused a dose-dependent relaxation of the isolated, pilocarpine-contracted guinea-pig trachea. This effect was blocked by the antagonists propranolol (non-selective) and practolol (beta 1-selective) but not by IPS 339 [(t-butylamino-3-ol-2-propyl)oximino-9-fluorene HCl] (beta 2-selective). The relaxing effect of terbutaline, a beta 2-selective adrenoceptor agonist, was more efficiently blocked by IPS 339 than by practolol. These data support the hypothesis that the guinea-pig trachea contains both beta 1- and beta 2-adrenoceptors mediating relaxation and that the beta 1-adrenoceptors are selectively stimulated by prenalterol. The efficacy of prenalterol was less than that of terbutaline, thus confirming its partial agonistic activity. In the absence of 17 beta-oestradiol, the ability of prenalterol to relax the pilocarpine-contracted trachea was lost. It is suggested that 17 beta-oestradiol may act as a functional antagonist to pilocarpine as it caused a partial relaxation itself.

References

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Jun 1, 1979·Pharmacological Research Communications·C OminiL Puglisi
Jul 1, 1978·Clinical and Experimental Pharmacology & Physiology·G S KehH Dowd
Apr 1, 1980·British Journal of Pharmacology·D IakovidisC Raper
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·U Johansson, B Waldeck
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·A HedbergE Carlsson
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·N RohmH J Schümann

Citations

Oct 1, 1985·British Journal of Pharmacology·C Advenier, J L Freslon
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M A JenkinsJ L Hopper
Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H MattssonT Olsson
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·H MattssonE Carlsson
Oct 1, 1982·European Journal of Clinical Pharmacology·C G Löfdahl, N Svedmyr
Apr 1, 1988·Journal of Endocrinological Investigation·C TantucciV Grassi
Jan 1, 1983·European Journal of Clinical Pharmacology·A P Greefhorst, C L van Herwaarden
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·L EkB Johansson

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