PMID: 6115005Jun 1, 1981

beta 1-Adrenoceptors mediating relaxation of the guinea-pig trachea: experiments with prenalterol, a beta 1-selective adrenoceptor agonist

The Journal of Pharmacy and Pharmacology
U Johansson, B Waldeck


In the presence of 17 beta-oestradiol, prenalterol, a beta-selective adrenoceptor agonist, caused a dose-dependent relaxation of the isolated, pilocarpine-contracted guinea-pig trachea. This effect was blocked by the antagonists propranolol (non-selective) and practolol (beta 1-selective) but not by IPS 339 [(t-butylamino-3-ol-2-propyl)oximino-9-fluorene HCl] (beta 2-selective). The relaxing effect of terbutaline, a beta 2-selective adrenoceptor agonist, was more efficiently blocked by IPS 339 than by practolol. These data support the hypothesis that the guinea-pig trachea contains both beta 1- and beta 2-adrenoceptors mediating relaxation and that the beta 1-adrenoceptors are selectively stimulated by prenalterol. The efficacy of prenalterol was less than that of terbutaline, thus confirming its partial agonistic activity. In the absence of 17 beta-oestradiol, the ability of prenalterol to relax the pilocarpine-contracted trachea was lost. It is suggested that 17 beta-oestradiol may act as a functional antagonist to pilocarpine as it caused a partial relaxation itself.


Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Jun 1, 1979·Pharmacological Research Communications·C OminiL Puglisi
Jul 1, 1978·Clinical and Experimental Pharmacology & Physiology·G S KehH Dowd
Apr 1, 1980·British Journal of Pharmacology·D IakovidisC Raper
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·U Johansson, B Waldeck
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·A HedbergE Carlsson
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·N RohmH J Schümann


Oct 1, 1985·British Journal of Pharmacology·C Advenier, J L Freslon
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M A JenkinsJ L Hopper
Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H MattssonT Olsson
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·H MattssonE Carlsson
Oct 1, 1982·European Journal of Clinical Pharmacology·C G Löfdahl, N Svedmyr
Apr 1, 1988·Journal of Endocrinological Investigation·C TantucciV Grassi
Jan 1, 1983·European Journal of Clinical Pharmacology·A P Greefhorst, C L van Herwaarden
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·L EkB Johansson

Related Concepts

Adrenergic beta-Agonists
Estradiol, (16 alpha,17 beta)-Isomer
Cavia porcellus
Muscle Relaxation Phase
Norepinephrine Receptors
Beta-adrenergic receptor

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.