PMID: 6132344Dec 1, 1982

beta 1-and beta 2-adrenoceptor stimulatory effects of prenalterol

Naunyn-Schmiedeberg's Archives of Pharmacology
H MattssonT Olsson

Abstract

Prenalterol, previously characterized as a functionally cardioselective partial beta-adrenoceptor agonist, was shown to relax K+ -elicited contractures in the uterine muscle from progesterone pretreated rats (pD2 7.7) and to increase beating rate in the rat right atrium (pD2 8.0) at about the same concentrations with maximal effects corresponding to 94 and 82% respectively of those of isoproterenol. Terbutaline, with equal maximal effects as isoproterenol, was 50 times more potent in the uterus (pD2 7.8) than in the right atrium (pD2 6.1). Both tissues displayed a high sensitivity to isoproterenol (pD2 9.1 in both tissues) indicating large receptor reserves for the full agonist. The maximal relaxing effect of prenalterol in the uterus was obtained at about a three-fold increase of the cyclic AMP content, which is similar to that obtained with isoproterenol at a corresponding relaxation. The effects in the uterine muscle of all three agonists were mediated through beta 2-adrenoceptors since beta 2-adrenoceptor blockers (ICI 118, 551 and IPS 339) antagonized the effects in concentrations which had only marginal effects on the atrial responses of the agonists. The beta 1-antagonists pafenolol and pamatolol in concentrations higher...Continue Reading

References

Jul 1, 1977·British Journal of Pharmacology·J L ImbsC G Wermuth
Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Apr 1, 1979·British Journal of Clinical Pharmacology·D H ScottD B Scott
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·U Johansson, B Waldeck
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·A HedbergE Carlsson
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·N RohmH J Schümann

Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·P M McCaffreyR G Shanks
May 1, 1985·British Journal of Pharmacology·E MaltaC Raper
Jul 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·E Skoubo-Kristensen, J Fryklund
Nov 1, 1987·British Journal of Clinical Pharmacology·P M McCaffreyR G Shanks

Related Concepts

Cyclic AMP, (R)-Isomer
Adrenergic beta-Agonists
Dose-Response Relationship, Drug
Pulse Rate
Novodrin
Dalzic
H-80-62
August Rats
Norepinephrine Receptors
Beta-adrenergic receptor

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.