PMID: 7543673Apr 1, 1995Paper

Beta 1 integrins in third trimester human placentae: no differential expression in pathological pregnancy

Placenta
M J DiversR J Lilford

Abstract

Integrins are a group of cell surface receptors that play important roles in cell-cell and cell-extracellular matrix interactions. The expression of trophoblast cell surface integrin subunits changes during placental development in normal pregnancy but the functional significance is unknown. The aim of this study was to investigate the expression of beta 1 integrins and their extracellular matrix ligands in human placenta and membranes in normal and pathological pregnancy using an avidin-biotin-peroxidase technique. Expression of the beta 1 integrins was similar in all study groups. Whilst there was some heterogeneity of expression of specific integrin alpha chains this was not characteristic of defined subject groups, variations occurring within all groups. Two distinct trophoblast subpopulations were demonstrated in the chorion laeve according to differential expression of beta 1 integrins. Trophoblast immediately adjacent to maternal decidua, which expressed alpha 1 rather than alpha 2, also comprised the majority of trophoblast in the basal plate; possession of the alpha 1, alpha 3, alpha 5, alpha 6 rather than alpha 2, alpha 3, alpha 5, alpha 6 phenotype may be important in the invasive potential of trophoblast populations...Continue Reading

References

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Citations

Oct 17, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Augusta M A LachmeijerReynir Arngrímsson
Dec 5, 2006·Journal of Perinatal Medicine·Jimmy EspinozaChong Jai Kim
Jan 9, 2016·Cell Adhesion & Migration·Juneo F Silva, Rogéria Serakides
Jul 27, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Fiona Lyall
Nov 20, 1998·American Journal of Obstetrics and Gynecology·G A Dekker, B M Sibai
Nov 20, 2002·American Journal of Obstetrics and Gynecology·Jan J BrosensIvo A Brosens
Apr 12, 2002·Placenta·J E CartwrightG St J Whitley
Aug 29, 2016·Prenatal Diagnosis·David W BarrettTina T Chowdhury
Jan 12, 2008·Reproductive Sciences·Claire E Kendal-Wright
Nov 25, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shiqin ZhuJinlong Ma

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