beta-1,3-glucanase inhibits activity of the killer toxin produced by the marine-derived yeast Williopsis saturnus WC91-2.

Marine Biotechnology
Ying PengJing Li

Abstract

The marine-derived Williopsis saturnus WC91-2 was found to produce very high killer toxin activity against the pathogenic yeast Metschnikowia bicuspidata WCY isolated from the diseased crab. It is interesting to observe that the purified beta-1,3-glucanase from W. saturnus WC91-2 had no killer toxin activity but could inhibit activity of the WC91-2 toxin produced by the same yeast. In contrast, the WC91-2 toxin produced had no beta-1,3-glucanase activity. We found that the mechanisms of the inhibition may be that the beta-1,3-glucanase competed for binding to beta-1,3-glucan on the sensitive yeast cell wall with the WC91-2 toxin, causing decrease in the amount of the WC91-2 toxin bound to beta-1,3-glucan on the sensitive yeast cell wall and the activity of the WC91-2 toxin against the sensitive yeast cells. In order to make W. saturnus WC91-2 produce high activity of the WC91-2 toxin against the yeast disease in crab, it is necessary to delete the gene encoding beta-1,3-glucanase.

References

Jul 1, 1997·Clinical Microbiology Reviews·W MaglianiL Polonelli
May 2, 2000·Applied and Environmental Microbiology·A SantosJ M Peinado
Mar 7, 2002·Trends in Molecular Medicine·Walter MaglianiLuciano Polonelli
Nov 18, 2006·Journal of Industrial Microbiology & Biotechnology·Fang GongJing Li
Sep 26, 2008·Diseases of Aquatic Organisms·Lin WangXianghong Wang

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Citations

Mar 3, 2010·Applied Microbiology and Biotechnology·Zhen-Ming ChiYing Peng
Oct 26, 2010·Extremophiles : Life Under Extreme Conditions·Ming-Xia HuaZhen-Ming Chi
May 18, 2011·Plant Molecular Biology·Sanjeewani SooriyaarachchiSherry L Mowbray
Oct 10, 2013·Critical Reviews in Biotechnology·Guang-Lei LiuZhen-Ming Chi
Nov 28, 2012·Antonie van Leeuwenhoek·Feng-Jun GuoZhen-Ming Chi

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