Beta 2-adrenoceptor-induced hypotension in the ganglion-blocked angiotensin II-supported rat

European Journal of Pharmacology
N L Brown, M Worcel

Abstract

An in vivo method is described to demonstrate vascular beta 2-adrenoceptor agonist and antagonist activity. Agonist activity was shown by the ability of i.v. injected compounds to reduce blood pressure in ganglion-blocked, phenoxybenzamine-treated, angiotensin II-supported rats. Procaterol was employed to assess the relative beta 2 blocking activity of propranolol IPS 339 and atenolol. Arunlakshana and Schild analysis of the data revealed that all these compounds were competitively beta 2 antagonists, their relative potencies being 100 : 80 : 0.56 respectively.

References

Nov 1, 1975·European Journal of Pharmacology·B N SinghR M Whitlock
Jul 1, 1977·British Journal of Pharmacology·J L ImbsC G Wermuth
Apr 1, 1981·The Journal of Pharmacy and Pharmacology·S R O'Donnell, K Walduck
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Angiotensin II, Val(5)-
Metazoa
Diastolic Blood Pressure
Ganglia, Spinal
Hypotension
Muscle, Smooth, Vascular
August Rats
Vasoconstrictor Agents

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