Beta 2-adrenoceptor-mediated increase in the slow inward calcium current in atrial cells

European Journal of Pharmacology
T Iijima, N Taira

Abstract

The effects of procaterol (beta 2-adrenoceptor agonist) on the slow inward calcium current (Isi) were examined in single cells of guinea-pig heart. Procaterol increased Isi in atrial cells, in the presence of atenolol (beta 1-adrenoceptor antagonist). The effect was abolished by ICI-118551 (beta 2-adrenoceptor antagonist). However, procaterol did not modify the membrane currents in ventricular cells. These results suggest that beta 2-adrenoceptor agonists bind to beta 2-adrenoceptors in atrial cells and augment Isi, but beta 2-adrenoceptors are not present in ventricular cells.

Citations

Jun 1, 1991·Cardiovascular Drugs and Therapy·A J Kaumann
Mar 4, 2008·Expert Opinion on Pharmacotherapy·Jeroen P P SmitsHanno L Tan

Related Concepts

ICI 118551, hydrochloride
Adrenergic alpha-Agonists
Proventil
Metazoa
Plasma Membrane
Ethanolamines
Cavia porcellus
Heart
Myocardium
Propanolamines

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