PMID: 9448584Feb 4, 1998Paper

beta 2-Glycoprotein I and anti-beta 2-glycoprotein I antibodies: where are we now?

British Journal of Rheumatology
M InançD A Isenberg

Abstract

beta 2-Glycoprotein I (beta 2-GPI), a plasma protein with in vitro anticoagulant properties, has been recognized to have an important role in the antiphospholipid syndrome (APS) as a cofactor and an (co)antigen in ELISA assays. Although beta 2-GPI levels were found to be increased in some patients with APS, the clinical value of measuring beta 2-GPI levels in APS is not known. Several reports have suggested that anti-beta 2-GPI antibodies may be a marker for the APS and might be more specific for the vascular complications of the APS than anticardiolipin antibodies. There have been major discoveries about phospholipid (PL) and antibody binding sites on beta 2-GPI, although more studies are needed. Reports of changes in cell membrane PL composition or exposure of other anionic molecules by apoptosis, cell activation and oxidative injury suggest mechanisms to explain beta 2-GPI binding and the generation of cryptic epitopes for aPL/anti-beta 2-GPI antibodies.

Citations

Jan 28, 2009·Current Rheumatology Reports·Eiji MatsuuraLuis R Lopez
Feb 3, 2005·International Immunopharmacology·Enrico Maria ZardiAntonella Afeltra
Oct 2, 2008·Lupus·E Matsuura, L R Lopez
Aug 9, 2003·Arthritis and Rheumatism·Ian P GilesAnisur Rahman
Sep 9, 2010·Clinical Orthopaedics and Related Research·Hany BedairCraig J Della Valle
Aug 30, 2005·Annals of the New York Academy of Sciences·Kazuko KobayashiEiji Matsuura
Apr 5, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M RenaudJ De Sèze

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