Beta 2-integrins in different forms of urticaria

The British Journal of Dermatology
N HaasB M Czarnetzki

Abstract

As urticarial lesions involve tissue invasion by inflammatory cells, and as beta 2-integrins play a central part in adhesion of leucocytes to endothelia, allowing their migration into the tissues, we have explored the distribution and sequential expression of these molecules in tissue sections from different forms of urticaria. Prick test weals (of 10 min duration) to common inhalant allergens showed only a minor increase of CD18, whereas in a case of cold urticaria CD11b and CD18 molecules were increasingly upregulated within the first 30 min after elicitation of the lesions. Skin test sites in delayed pressure urticaria, and urticarial lesions (> 6 h duration) of acute and chronic recurrent urticaria also showed marked upregulation of CD11b and CD18, and to a lesser extent of CD11a, but this did not strongly correlate with the intensity of the mixed cellular infiltrate. Non-lesional skin showed expression of beta 2-integrins in chronic urticaria, delayed pressure urticaria, and less so in acute urticaria, suggesting generalized leucocyte activation. This analysis of integrins thus suggests an early and extensive involvement of these molecules in the pathological events associated with the evolution of urticarial lesions.

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Citations

Aug 12, 1999·Allergy·I BoehmT Bieber
Sep 13, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·N CassanoGa Vena
Jan 13, 2017·Clinical and Translational Allergy·Emek KocatürkClive Grattan
May 29, 1998·The British Journal of Dermatology·E ToppeB M Henz
Feb 11, 2003·International Journal of Immunopathology and Pharmacology·G. A. VenaC. Coviello
Jul 18, 2002·International Journal of Dermatology·Alessandra FrezzoliniGino A Vena

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