Beta 2 microglobulin expression in keratoacanthomas and squamous cell carcinoma

The British Journal of Dermatology
R GrahamJ R Nash


The cell surface expression of beta-2-microglobulin (beta 2 M) was investigated in 33 keratoacanthomas (KA) and 58 squamous cell carcinomas (SCC) to determine whether this antigen was expressed to a different extent in these two conditions and, thus, whether this constitutes a reliable and practical test for distinguishing them. Loss of beta 2 M expression was not a reliable feature for distinguishing between KA and SCC and seemed to be related more to the degree of cellular differentiation and maturation, than to malignancy as such.


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Related Concepts

Surface Antigens
Beta-2 Microglobulin
Squamous Cell Carcinoma
Malignant Neoplasm of Skin

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