PMID: 6171030Jan 1, 1981Paper

beta 2-Microglobulin is bound to streptococcal M protein

Scandinavian Journal of Immunology
L BjörckG Kronvall

Abstract

The presence of receptors for three human proteins (fibrinogen, IgG, and beta 2-microglobulin (beta 2m)) was studied in group A streptococcal strains. M type 1, 12 and 14, and in M protein-negative variants of these strains. Fibrinogen binding was detected in all six strains. IgG did not bind to the two type-12 strains and uptake was low in both type-14 strains. The type-1, M protein-positive strain was negative in binding experiments with radiolabelled IgG, whereas the M protein-negative variant was strongly positive. Aggregated beta 2m showed a high degree of reactivity with the M protein-positive strains but not with the corresponding M protein-negative variants. The results indicate that the receptor for aggregated beta 2m is located on M protein in group A streptococci.

References

Jan 1, 1978·Scandinavian Journal of Immunology·L TrägårdhP A Peterson
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C TerhorstJ L Strominger
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonL Ostberg
May 19, 1972·Nature·W F Bodmer
Jan 1, 1972·Annual Review of Genetics·J A Gally, G M Edelman
Dec 1, 1973·The Journal of Experimental Medicine·H M GreyJ L Strominger
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonJ B Lindblom
Mar 1, 1974·Bacteriological Reviews·E N Fox
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·K NakamuroD Pressman
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonG M Edelman
Aug 1, 1959·The Journal of Experimental Medicine·R C LANCEFIELD
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER
Oct 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·F S KANTOR, R M COLE

❮ Previous
Next ❯

Citations

Dec 1, 1982·European Journal of Clinical Microbiology·L M SwitalskiT Wadström
Jul 1, 1984·Scandinavian Journal of Immunology·L BjörckR Sundler
Jun 18, 2016·FEBS Letters·Stephan BrouwerMark J Walker
Feb 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·H MiörnerG Kronvall
Aug 1, 1993·FEMS Immunology and Medical Microbiology·K H SchmidtW Köhler
Sep 1, 1983·Infection and Immunity·G S ChhatwalH Blobel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
B WagnerW Köhler
The Journal of Infectious Diseases
T Wadström, S Tylewska
Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
K H SchmidtW Köhler
© 2021 Meta ULC. All rights reserved