PMID: 58956Jul 1, 1976

Beta 2-microglobulin is selectively associated with H-2 and TL alloantigens on murine lymphoid cells

The Journal of Experimental Medicine
E S VitettaJ W Uhr

Abstract

We have used a rabbit antiserum prepared against purified rat beta2-microglobulin to immunoprecipitate molecules from lysates of radioiodinated murine thymocytes and splenocytes. All the molecules that are reactive with this serum have subunits of 44,000 and 12,000 and can be identified as H-2 and TL antigens. Thus, the anti-beta2mu serum can deplete lysates of the majority of the TL and H-2 atigens which can be subsequently recognized by alloantisera. If TL and H-2 are precipitated from the lysates before the addition of anti-beta2mu, no beta2mu-reactive molecules remain. Our results indicate that Ia antigens cannot be depleted from the lysates with anti-beta2mu. The studies also suggest that TL and H-2 heavy chains can exist as both monomers and dimers. These observations are discussed with regard to previous studies concerning the native structure of H-2 and TL antigens.

References

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Citations

Jan 1, 1979·Journal of Supramolecular Structure·J R Glenney, E F Walborg
Jan 1, 1981·Immunogenetics·J MichaelsonH Yudkowitz
Dec 1, 1981·Immunogenetics·E Rothenberg, D Triglia
Jan 1, 1983·Immunogenetics·K YokoyamaS G Nathenson
Sep 1, 1979·Molecular Immunology·M D Poulik, O Smithies
Dec 1, 1980·Molecular Immunology·P B Wolfe, J J Cebra
Sep 1, 1982·Molecular Immunology·M J SoloskiE S Vitetta
Nov 1, 1991·Molecular Immunology·G P EinhornM J Soloski
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J D CapraJ Klein
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J W Goding, I D Walker
Oct 1, 1979·The Journal of Experimental Medicine·E Rothenberg, E A Boyse
May 1, 1981·The Journal of Experimental Medicine·M J SoloskiE S Vitetta
Dec 1, 1988·Journal of Interferon Research·A M LiberatiG Peretti
Jan 1, 1978·Scandinavian Journal of Immunology·F K StevensonG T Stevenson
Jan 1, 1979·Immunological Reviews·F M BrodskyW F Bodmer
Mar 1, 1982·European Journal of Cancer & Clinical Oncology·M A LuceroE Falcoff
May 29, 1979·Biochemistry·F T GatesT J Kindt
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·M J SoloskiJ W Uhr
Nov 1, 1977·European Journal of Immunology·E S VitettaJ W Uhr
Jul 1, 1980·Tissue Antigens·F M BrodskyW F Bodmer
Feb 7, 2019·Frontiers in Immunology·Yuan LiuGuixiu Shi
Jan 1, 1979·CRC Critical Reviews in Clinical Laboratory Sciences·M D PoulikJ Shuster

Related Concepts

Tumor Antigens
Beta(1)CA Globulin
Beta-2 Microglobulin
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Alloantigens
Leukemia
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Spleen
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