PMID: 6164344Apr 1, 1981Paper

beta 2-Microglobulin levels in serum and urine of rheumatoid arthritis patients on gold therapy

Annals of the Rheumatic Diseases
D LattM I Jayson

Abstract

The levels of beta 2-microglobulin (beta 2-m) in serum and urine of 24 seropositive patients with rheumatoid arthritis (RA) treated with regular gold (sodium aurothiomalate) injections have been investigated. The values obtained were compared with levels from 20 seropositive patients with RA treated only with nonsteroidal anti-inflammatory drugs and 20 age and sex matched normal controls who had received no medication. A significant increase of urinary beta 2-m levels was found in the gold-treated RA group. No correlation between dose of gold received and the levels of beta 2-m in the urine could be established. There was also no correlation between the erythrocyte sedimentation rate (ESR) or total lymphocyte count and beta 2-m levels in serum or urine. We conclude that serum and urinary beta 2-m levels appear to be poor indices of joint inflammation, but sequential urinary beta 2-m levels may prove valuable in monitoring the development of renal tubular lesions due to gold therapy.

References

Aug 1, 1978·Annals of the Rheumatic Diseases·D ManicourtS Orloff
Dec 1, 1977·Annals of the Rheumatic Diseases·B V SkrifvarsG N Tallqvist
May 1, 1979·Arthritis and Rheumatism·W F Kean, T P Anastassiades
Dec 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·P E EvrinI Berggård
Jan 1, 1973·Nephron·L WibellI Berggård
Dec 1, 1971·Experimental and Molecular Pathology·A H NagiA Z Barabas
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·P E Evrin, L Wibell
Nov 1, 1970·Arthritis and Rheumatism·D S SilverbergR A Ulan
Nov 1, 1970·Arthritis and Rheumatism·C A Vaamonde, F R Hunt

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Citations

Feb 27, 2010·The American Journal of the Medical Sciences·Hyoun-Ah KimChang-Hee Suh
Dec 29, 2009·Toxicology and Applied Pharmacology·Estelle Marrer, Frank Dieterle
Jan 1, 1986·Scandinavian Journal of Rheumatology·J FontA Balcells
Jan 1, 1991·Critical Reviews in Toxicology·A Bernard, R R Lauwerys
Aug 1, 1996·Biological Reviews of the Cambridge Philosophical Society·A B LockhartJ Antonovics
Oct 18, 2012·Angewandte Chemie·Pakorn PreechaburanaDaniel Filippini
Nov 1, 1987·Kidney International·G H Schardijn, L W Statius van Eps

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