Apr 25, 1986

Beta 2 receptors on myocardial cells in human ventricular myocardium

The American Journal of Cardiology
M R Bristow, R Ginsburg

Abstract

Beta 2-adrenergic receptors comprise 40% of the total beta-receptor population in failing human right ventricles, as deduced from computer modeling of iodine-125 iodocyanopindolol-ICI 118,551 competition curves. A myocardial cell origin of at least some of the beta 2 subpopulation was demonstrated by documenting a beta 2-receptor mediated positive inotropic response to the selective beta 2 agonist zinterol. It is concluded that beta 2-adrenergic receptors are present on human ventricular myocardial cells.

Mentioned in this Paper

Myocardial Contraction
ICI 118551
Left Ventricular Structure
ICI 118551, hydrochloride
Right Ventricular Structure
Isolated Noncompaction of the Ventricular Myocardium
Myocardium
Propanolamines
Zinterol
Adrenergic Receptor

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